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FLASH GENE
Symbol MYRIP contributors: mct - updated : 15-02-2019
HGNC name myosin VIIA and Rab interacting protein
HGNC id 19156
Location 3p22.1      Physical location : 39.851.302 - 40.301.804
Synonym name
  • exophilin 8
  • rab effector MYRIP
  • Slp homologue lacking C2 domains
  • synaptotagmin-like protein homologue lacking C2 domains-c
    • Synonym symbol(s) SLAC2C, exophilin 8, SLAC2-C, FLJ44025, MGC130034, MGC130035, DKFZp586F1018, EXPH8
    DNA
    TYPE functioning gene
    STRUCTURE 451.41 kb     17 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    17 - 4884 - 859 - 2007 17827149
    17 - 4857 - 859 - 2007 17827149
    16 - 4851
    16 - 4909 - 770 - 2007 17827149
    15 - 4667 - 672 - 2007 17827149
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    Urinarykidney    
    Visualeye    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier/liningretinal pigment epithelium (RPE)  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Skin/Tegumentmelanocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal SlP HO domain (SHD)
  • a C terminal,myosin binding domain
  • a most C terminal actin binding conserved region
    • HOMOLOGY
    interspecies ortholog to murine Myrip
    Homologene
    FAMILY AKAP family
    CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,granule
    intracellular,cytoplasm,cytoskeleton
    intracellular,nuclear envelope
    text melanosomes
    basic FUNCTION
  • RAB27 effector
  • RAB27A, MYRIP and MYO7A bridges retinal melanosomes to the actin cytoskeleton and thereby mediates the local trafficking of these organelles
  • functions as a scaffolding protein that links PRKA to components of the exocytosis machinery
  • versatile RAB27A-associated myosin-activating protein that mediates cellular activation of MYO5A and MYO7A via non-overlapping domains
  • effector protein of the small GTPase RAB27A and is specifically localized on retinal melanosomes and secretory granules
  • transiently traps insulin granules into the cortical actin network close to the microtubule plus-ends and supplies them for release during the stimulation
  • MYRIP couples the retention of secretory granules (SGs) in the cell cortex, their transport to the PM, and their attachment to the plasma membrane (PM), and thus promotes secretion
  • is implicated in hormone secretion, and MYRIP is important for beta-cell function
  • reported to play a role in anchoring secretory granules within the actin cortex, due to its direct binding activities to RAB27A on the granule membrane and to F-actin and its motor protein, MYO5A
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
  • complex with RAB27A and MYO7A bridging retinal melanosomes to actin skeleton
  • MYO5A forms a tripartite complex with RAB27A and its effector MYRIP
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to MYO5A, MYO7A, RABZ7A/B (GTP bound form), actin
  • interacts with MYO5A lacking melanocyte-specific exon F
  • MYRIP functionally links insulin vesicle transport and GCG signaling
  • role of MYRIP in regulating Weibel-Palade body (WPB) trafficking and exocytosis is mediated largely through its interaction with actin rather than with MYO5A
  • MYRIP accumulates granules in the cortical F-actin network not by direct interaction with MYO5A, but by indirect interaction with a specific form of MYO7A through its previously unknown binding partner, RIMBP2 (28673385)
    • cell & other melanosomes
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS