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FLASH GENE
Symbol MYRF contributors: mct/npt - updated : 26-03-2014
HGNC name myelin regulatory factor
HGNC id 1181
Location 11q12.2      Physical location : -
Genatlas name myelin gene regulatory factor
Synonym name
  • best macular dystrophy-related protein
  • KIAA0954 protein
  • gene model 98
  • chromosome 11 open reading frame 9
  • hypothetical protein LOC745
  • Synonym symbol(s) KIAA0954, MGC10781, C11orf9, GM98, MRF, NDT80
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem
    STRUCTURE 35.87 kb     27 Exon(s)
    regulatory sequence Promoter
    Binding site   enhancer
    text structure
  • a SOX10 responsive enhancer to an evolutionarily conserved element in intron 1 of the MYRF gene
  • MAPPING cloned Y linked N status provisional
    Map cen - MRF - FEN1 - VMD2 - FTH1 - qter
    Authors Stöhr (00)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    27 - 5926 - 1151 - 2000 10828591
    26 - 5745 - 1111 - 2000 10828591
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivestomach   highly
    Nervousbrainbasal nuclei  highly Homo sapiens
    Reproductivefemale systemuterus   
    Respiratoryrespiratory tractlarynx  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentral    Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two transmembrane helices
  • two proline-rich region
  • a MYRF domain indeed serves as an intramolecular chaperone that facilitates MYRF trimerization and proteolysis
  • HOMOLOGY
    interspecies homolog to C.Elegans F21A10.2
    intraspecies homolog to protein Best's macular dystrophy
    Homologene
    FAMILY
  • MRF family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • playing a necessary role for the generation of mature myelin-gene-expressing oligodendrocytes within the CNS (Emery 2009)
  • transcriptional regulator vital for the generation of myelinating oligodendrocytes, with an analogous role in the CNS to that of EGR2 in the PNS (Emery 2009)
  • is required for the generation of CNS myelination during development and also for its maintenance in the adult
  • is a novel example of a membrane-associated transcription factor and provide a direct molecular mechanism for its regulation of oligodendrocyte differentiation and CNS myelination
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • is an oligodendrocyte-specific target of SOX10 (MYRF cooperates with SOX10 to implement the myelination program as evident from the physical interaction between both proteins and the synergistic activation of several myelin-specific genes
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS