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FLASH GENE

Symbol

MYOZ3

contributors: npt/ - updated : 06-06-2007

HGNC name	myozenin 3
HGNC id	18565

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	5q33.1      Physical location : 150.040.403 - 150.058.925
Synonym name	calsarcin 3
	FATZ related protein 3
Synonym symbol(s)	CS3, CS-3, FRP3

DNA

TYPE	functioning gene
STRUCTURE	18.50 kb     7 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

text	Variants 1 and 2 encode the same protein

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 - splicing 3447 isoform 1 27.2 251 - Scannapieco (unpublished) variant 2 - splicing 1039 isoform 1 - 205 - Scannapieco (unpublished)

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain         Reproductive male system prostate       Respiratory lung

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies

ortholog to murine Myoz3

Homologene

FAMILY	calsarcin family
	myozenin family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic

basic FUNCTION

involved in Z-disc structure and signal transduction in striated muscle (Frey 2002)

CELLULAR PROCESS

cell communication

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

binding to calcineurin, alpha actinine (ACTN2, ACTN1), FLNC, TCAP (Z dix protein), LDB3

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS