basic FUNCTION
| smooth and cardiac muscle-specific transcriptional coactivator of serum response factor |
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acts as a cofactor of SRF and modulates SRF-target genes |
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an important component of a molecular switch for the smooth muscle differentiation program (acting as a bifunctional switch for smooth versus skeletal muscle differentiation) |
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functions as a transcriptional repressor of MYOG, inhibiting skeletal muscle differentiation while activating SMC-specific genes |
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playing a role in repressing the skeletal muscle differentiation program and acts as a bifunctional molecular switch for the smooth versus skeletal muscle phenotypes |
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may be contributing to heart hypertrophy |
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cardiac- and smooth muscle-specific SAP domain transcription factor that functions as a coactivator for serum response factor (SRF), which controls genes involved in muscle differentiation and cell proliferation |
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necessary for insulin and IGF1 to induce hypertrophy |
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Regulates the expression of a set of cardiac and smooth muscle-specific genes |
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Plays a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage |
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a master regulator of smooth muscle gene expression |
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acts as a transcriptional repressor of Myog and as a bifunctional molecular switch for smooth versus skeletal muscle phenotypes |
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plays a critical role in differentiation of neural crest-derived SMCs populating the great arteries abd in maintenance of the contractile SMC phenotype |
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acts as a potent repressor of MyoD-mediated skeletal muscle cell differentiation in an SRF-CArG element independent manner |
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MYOCD controls amyloid beta-peptide clearance from cerebral vascular smooth muscle cells in Alzheimer’s disease (AD), the degree of cerebral amyloid angiopathy (CAA) and focal amyloid beta-peptide brain accumulations in animal models of CAA and AD |
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required for maintenance of cardiomyocyte structure and sarcomeric organization and cell-autonomous loss of myocardin in cardiac myocytes triggers programmed cell death |
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transcriptional coactivator required for maintenance of heart function and, ultimately, cardiomyocyte survival |
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may function there to extinguish the skeletal muscle program of differentiation in favor of smooth muscle cells differentiation |
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is a cardiac and smooth muscle-specific expressed transcriptional coactivator of Serum Response Factor (SRF) and is able to potently activate cardiac and smooth muscle gene expression during development |
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important molecular switch for the programs of SMC and cardiac myocyte differentiation |
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important regulatory role of SOX9 and MYOCD in controlling the transcription program during Smooth muscle cells (SMCs) transdifferentiation into chondrocytes |
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antagonism between SOX9 and MYOCD as central regulators in controlling SMC and chondrogenic gene transcription in SMCs in response to injury |
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is a muscle lineage-restricted transcriptional coactivator that has been shown to transduce extracellular signals to the nucleus required for SMC differentiation |
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functions as a transcriptional coactivator of SRF and is sufficient and necessary for smooth muscle gene expression |
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MYOCD plays likely a critical role in Ca(2+) signal-induced cardiomyocyte hypertrophy, which may serve as a novel mechanism that is important for cardiac hypertrophy |
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is a muscle-restricted transcriptional coactivator that activates a serum response factor (SRF)-dependent gene program required for cardiogenesis and embryonic survival |
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is required for maintenance of vascular and visceral smooth muscle homeostasis during postnatal development |
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MYOCD and its relative MRTF-A (MKL1) are transcriptional coactivators that control genes which promote smooth muscle differentiation |