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FLASH GENE
Symbol MYO5B contributors: mct - updated : 27-08-2015
HGNC name myosin VB
HGNC id 7603
Corresponding disease
MVID microvillus inclusion disease
Location 18q21.1      Physical location : 47.349.155 - 47.721.451
Synonym name MYO5B variant protein
Synonym symbol(s) KIAA1119
DNA
TYPE functioning gene
STRUCTURE 372.28 kb     40 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
MIZ1 18q12.1-q12.3 deleted in colorectal carcinoma TCEB3L2 18q12,3 deleted in colorectal carcinoma TCEB3L 18q21.1 deleted in colorectal carcinoma DKFZP564D1378 18q21.1 hypothetical protein DKFZp564D1378 HSPC039 18q12 HSPC039 protein LOC390851 18 similar to RIKEN cDNA C230094B15 LOC201411 18q21.1 similar to Thiopurine S-methyltransferase (Thiopurine methyltransferase) MADH2 18q21 MAD, mothers against decapentaplegic homolog 2 (Drosophila) LOC201501 18q21.1 similar to B230208J24Rik protein HEIL1 KIAA0427 18q21.1 KIAA0427 MADH7 18q21.1 MAD, mothers against decapentaplegic homolog 7 (Drosophila) FLJ20071 RPL17 18q21.1 ribosomal protein L17 LOC390852 18 similar to signal recognition particle 72kDa LIPG 18q21.1 lipase, endothelial ACAA2 18q21.1 acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase) MYO5B 18q12 myosin VB FLJ32743 18q21.1 hypothetical protein FLJ32743 MBD1 18q21 methyl-CpG binding domain protein 1 CGBP 18q12 methyl-CpG binding domain protein 1 MGC10200 18q21.1 hypothetical protein MGC:10200 LOC390853 18 similar to acidic ribosomal phosphoprotein P0 MAPK4 18q21.2-q21.3 mitogen-activated protein kinase 4 B29 18q21 mitogen-activated protein kinase 4 ME2 18q21 malic enzyme 2, NAD(+)-dependent, mitochondrial ELAC1 18q21 elaC homolog 1 (E. coli) MADH4 18q21.1 MAD, mothers against decapentaplegic homolog 4 (Drosophila) LOC51320 18q21.1 hypothetical protein LOC51320 LOC390854 18 similar to neuroepithelial cell transforming gene 1; guanine nucleotide regulatory protein (oncogene); Rho guanine nucleotide exchange factor (GEF) 8 LOC390855 18 similar to 40S ribosomal protein S8 DCC 18q21.1 deleted in colorectal carcinoma
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
40 - 9520 213.5 1848 - -
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   moderately
Digestiveintestinelarge intestinecolon moderately
 intestinesmall intestine  highly
 liver   lowly
 stomach   specific
Endocrinethyroid   moderately
Reproductivefemale systembreastmammary gland highly
Respiratorylung   moderately
Urinarykidney   highly
cell lineage
cell lines
fluid/secretion predominantly in lymph
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a myosin head-like domain
  • six IQ domains
  • a dilute domain
  • HOMOLOGY
    interspecies homolog to rattus Myo5b (90.1 pc)
    homolog to murine Myo5b (90.4 pc)
    Homologene
    FAMILY
  • myosin superfamily
  • CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleolus
    text
  • present in nucleoli where it co-localises with RNA polymerase I, and newly synthesised ribosomal RNA (rRNA), indicating that it may play a role in transcription
  • basic FUNCTION
  • having a motor activity
  • regulating plasma membrane recycling through its association with Rab11a
  • RAB11A, MYO5B, RAB11FIP2 regulate plasma membrane recycling in epithelial cells
  • play critical roles in the proper trafficking and recycling of a large number of diverse intracellular cargoes (Roland 2009)
  • Ca2+-sensitive motor, conducts spine trafficking during long-term potentiation of synaptic strength
  • may provide a molecular basis for actin-dependent organelle transport and regulate membrane trafficking along the recycling pathway in polarized epithelial cells
  • multifunctional motors recruited by a variety of Rab proteins to perform multiple tasks in a variety of distinct and overlapping recycling system (Roland 2009)
  • potentially serves a role in rRNA transcription
  • with other myosin 5, are important modulator of synaptic plasticity
  • having an important role in the transport and turnover of mRNA
  • MYO5A, MYO5B, and MYO5C, are involved in transport of multiple cargoes
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • MYO5B/RAB11A/RAB11FIP2 platform is spatially involved in the regulation of CD207 trafficking at two distinct sites within live cells
  • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
  • protein
  • interacting with RAB11FIP2
  • binding to actin
  • binding to calmodulin
  • interacting with CFTR (required for CFTR recycling in RAB11a-specific apical recycling endosomes in polarized human airway epithelial cells)
  • can interact with RAB10, based on the presence of an alternatively spliced exon sequence (Roland 2009)
  • interact with RAB11A and RAB8 in different recycling systems
  • effector for RAB8a, RABb10, and RABb11a, all of which are implicated in regulating different pathways for recycling of proteins to the plasma membrane (MYO5B is required for apical membrane trafficking and de novo lumen formation, dependent on association with both RAB8a and RAB11a)
  • RAB10 interaction with myosin Vb (MYO5B) determines the formation of RAB10 carriers and is important for axon development
  • tripartite association of RAB11A with both RAB11FIP2 and MYO5B regulates recycling endosome trafficking
  • membrane tethering mediated by endosomal RAB11A is drastically and selectively stimulated by its cognate Rab effectors, MYO5A and MYO5B, in a GTP-dependent manner
  • cell & other
    REGULATION
    Other motor functions of MYO5A and MYO5B are regulated by a tail inhibition mechanism
    ASSOCIATED DISORDERS
    corresponding disease(s) MVID
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    aberrantly methylated promoter associated CpG islands in acute lymphocytic leukemia (Kuang 2008)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS