SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,Golgi
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| intracellular,cytoplasm,cytosolic,granule
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| intracellular,cytoplasm,cytosolic,vesicle
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| intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
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| intracellular,nucleus
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text
| centrosomes |
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motor protein associated with synaptic vesicles |
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basic FUNCTION
| unconventional non muscle, apparently non filamentous myosin |
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major actin-based vesicle transport motor that binds to one of its cargos, the melanosome, by means of a RAB27A/MLPH receptor ( |
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is required for the peripheral accumulation of melanosomes in melanocytes (O'Sullivan 2004) |
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processive motor protein, moving vesicles (melanosomes) on actin tracks through a characteristic cycle of interaction with actin, the rate limiting step of the cycle being the ADP release |
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despite its known motor activity, directly mediates stable attachment of secretory granule at the plasma membrane |
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role for both myosin Va and VAMP2 in oligodendrocyte function as it relates to myelination |
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potentially involved in a transient transport or tethering function in the perinuclear region |
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play critical roles in the proper trafficking and recycling of a large number of diverse intracellular cargoes |
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multifunctional motors recruited by a variety of Rab proteins to perform multiple tasks in a variety of distinct and overlapping recycling system |
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essential role in cancer cell migration and metastasis, suggesting a novel target for SNAI1 in its regulation of cancer progression |
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mediates correct positioning of PRKAR1A in a postsynaptic microdomain, presumably by tethering PRKAR1A to the actin cytoskeleton |
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with other myosin 5, are important modulator of synaptic plasticity |
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implication of myosin Va and RAB3D in the maturation of SGs (secretory granules) where they participate in overlapping but not identical tasks |
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transports the endoplasmic reticulum into the dendritic spines of Purkinje neurons |
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having an important role in the transport and turnover of mRNA |
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role of MYO5A in Purkinje cells spines is not sufficient for motor coordination |
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RAB27A/MYRIP/MYO5A complex is involved in linking Weibel-Palade bodies (WPB) to the peripheral actin cytoskeleton of endothelial cells to allow full maturation and prevent premature secretion of VWF |
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plays a key role in the transport of cargo to the plasma membrane |
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has also been implicated in the assembly and maintenance of P-bodies (processing bodies), cytoplasmic foci that are involved in mRNA storage and degradation |
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has no non-redundant role in the secretion of dense and alpha-granules or other functional responses in platelets |
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MYO5A and kinesin play likely key roles in the assembly and subsequent transport of FMR1 granules along microtubules to the periphery of the cell |
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MYO5A is likely involved in mRNA trafficking both in the central and peripheral nervous systems 8) |
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MYO5A and dynamic actin oppose microtubules to drive long-range organelle transport |
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is an actin-based molecular motor responsible for transport and positioning of a wide array of intracellular cargoes |
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MYO5A and endoplasmic reticulum calcium channel complex regulates membrane export during axon guidance |
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