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FLASH GENE
Symbol MYO1G contributors: mct/npt - updated : 02-04-2010
HGNC name myosin IG
HGNC id 13880
Location 7p13      Physical location : 45.002.259 - 45.018.704
Synonym name
  • minor histocompatibility antigen HA-2
  • MYO1G variant protein
  • Synonym symbol(s) HA2, MGC142104, MHAG
    DNA
    TYPE functioning gene
    STRUCTURE 16.41 kb     22 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    22 - 3313 116.4 1018 - Pierce (2001)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  specific
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/ImmuneT cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • Myo1PH domain, present also in long tail myosins, and in a probable ancestral protein in prokaryotes, likely playing universal roles in myosin I membrane association, but different isoforms have diverged in their binding specificity (Patino-Lopez 2010)
  • a short tail
  • a head domain that does not need to be a functional motor (Olety 2010)
  • HOMOLOGY
    Homologene
    FAMILY
  • myosin superfamily
  • CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION     plasma membrane
    text localizes to the plasma membrane (Patino-Lopez 2010)
    basic FUNCTION
  • specifically localized at the plasma membrane, and participates in the regulation of cell elasticity in haematopoietic cells (Olety 2010)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • can interact with F-actin (Olety 2010)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS