motifs/domains
| N terminal motor domain containing ATP and actin-binding sites |
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a neck with three IQ calmodulin or calmodulin-like light chain binding domains |
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two nucleolar localization signals (NoLS), that are functional and necessary for nucleolar localization of specifically MYOIC isoform B |
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a tail with a TH motif (short tail), that can inhibit kinesin motor activity, increase the stability of microtubules (MTs), and form crosslinks between MTs and F-actin |
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a C terminal globular domain, implicated in membrane binding |
SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,cytosolic
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| intracellular,cytoplasm,cytoskeleton
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| intracellular,nucleus,nucleoplasm
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| intracellular,nucleus,nucleolus
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| intracellular,nuclear envelope,pore
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text
| single headed member of the myosin superfamily that localizes to the cytoplasm and the nucleus, where it is involved in transcription by RNA polymerases I and II, intranuclear transport, and nuclear export |
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detected in lipid rafts of B cells |
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is typically localized at the plasma membrane as a dense fibrous network and marginally in the nucleoplasm as punctate foci |
basic FUNCTION
| unconventional, apparently non filamentous, may be involved in the adaptation response in the inner ear |
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involved in intracellular movements |
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cooperates with WICH to facilitate transcription on chromatin |
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general transcription factor for RNA polymerases, involved in transcription by RNA polymerase I |
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playing a crucial role for the formation of the first phosphodiester bond during transcription initiation |
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participates along with nuclear actin in transcription and chromatin remodeling |
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in stereocilia of the hair cells in the inner ear, presumably serves as the adaptation motor, which regulates the opening and closing of transduction channels (A |
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mediates the cycling of SLC2A4 transporters in adipocytes by promoting the fusion of SLC2A4-containing vesicles with the cell membrane |
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novel MYO1C-dependent molecular mechanism that mediates the dynamic organization of KIRREL and NPHS1 at the slit diaphragm and is critical for podocyte function |
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is potentially involved in the regulation of MT function during mitosis |
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MYO1C-facilitated G-actin transport might be a critical node for control of cell polarity and motility |
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contributed to insulin-dependent actin filament remodeling |
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is an important mediator of VEGF-induced KDR delivery to the cell surface and plays a role in angiogenic signaling |
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involved in driving the recycling of lipid-raft enriched membranes from the perinuclear recycling compartment to the cell surface |
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role for MYO1C in regulating the actin structures, as MYO1C manipulations lead to loss of the actin filaments and to similar ER phenotype as observed after actin depolymerization |
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having nuclear myosin1 (NM1) function |
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tumor suppressor activity of INPP5K and MYO1C, with overlapping roles in phosphoinositide (PI) 3-kinase/Akt signaling, known to be vital for the cell growth and survival |