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FLASH GENE
Symbol MYO16 contributors: mct - updated : 23-08-2013
HGNC name myosin XVI
HGNC id
Location 13q13.33      Physical location : 109.248.499 - 109.860.355
Synonym name
  • myosin heavy chain Myr 8
  • neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 3
    • Synonym symbol(s) RP11-54H7.1, MYR8, Myo16b, NYAP3
    DNA
    TYPE functioning gene
    STRUCTURE 611.85 kb     35 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    35 - 6874 - 1858 - 2001 11588169
    35 - 7436 - 1880 - 2001 11588169
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • may play a regulatory role in cell cycle progression
  • activate PI3K and concomitantly recruit the downstream effector WAVE complex to the close vicinity of PI3K and regulate neuronal morphogenesis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interact with the WAVE1 complex which mediates remodelling of the actin cytoskeleton after activation by PI3K-produced PIP(3) and RAC1
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS