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FLASH GENE
Symbol MYL3 contributors: - updated : 13-07-2006
HGNC name myosin, light polypeptide 3, alkali; ventricular, skeletal, slow
HGNC id 7584
Corresponding disease
CMH8 cardiomyopathy, familial, hypertrophic, 8
Location 3p21.3      Physical location : 46.899.356 - 46.904.973
Synonym name essential myosin light chain,ventricular
Synonym symbol(s) ELC, MLC1-SB, MLC1V, MYL1V
DNA
TYPE functioning gene
STRUCTURE 5.00 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
Physical map
LARS2 3p21.3 leucyl-tRNA synthetase 2, mitochondrial LIMD1 3p21.3 LIM domains containing 1 SACM1L 3p21.3 SAC1 suppressor of actin mutations 1-like (yeast) XT3 3p21.3 SAC1 suppressor of actin mutations 1-like (yeast) LZTFL1 3p21.3 leucine zipper transcription factor-like 1 CCR9 3p21.3 chemokine (C-C motif) receptor 9 FYCO1 3p21.3 FYVE and coiled-coil domain containing 1 CXCR6 3p21.3 chemokine (C-X-C motif) receptor 6 XCR1 3p21.3-p21.1 chemokine (C motif) receptor 1 LOC391533 3 similar to Vascular endothelial growth factor receptor 1 precursor (VEGFR-1) (Vascular permeability factor receptor) (Tyrosine-protein kinase receptor FLT) (Flt-1) (Tyrosine-protein kinase FRT) (Fms-like tyrosine kinase 1) CCR1 3p21.31 chemokine (C-C motif) receptor 1 CCR3 3p21.31 chemokine (C-C motif) receptor 3 LTF 3p21.31 lactotransferrin TMEM7 3p21.3 transmembrane protein 7 LRRC2 3p21.3 leucine-rich repeat-containing 2 TDGF1 3p21.31 teratocarcinoma-derived growth factor 1 FLJ36525 3p21.31 hypothetical protein LOC259173 TMIE 3p21 hypothetical protein LOC259173 TSP50 3p14-p12 testes-specific protease 50 TESSP5 3p21.31 testis serine protease 5 LOC391534 3 hypothetical gene supported by AK128390 TESSP2 3p21.31 testis serine protease 2 MYL3 3p21.3 myosin, light polypeptide 3, alkali; ventricular, skeletal, slow PTHR1 3p21.3 parathyroid hormone receptor 1 MGC23918 3p21.31 hypothetical protein MGC23918 KIAA0540 3p21.31 KIAA0540 protein LOC391535 3 similar to p75-like apoptosis-inducing death domain protein PLAIDD HYPB 3p21.2-q22.2 similar to p75-like apoptosis-inducing death domain protein PLAIDD MRP63P3 3p21.31 mitochondrial ribosomal protein 63 pseudogene 3 KIF9 3p21.31 kinesin family member 9 KIAA0795 3p21.31 kinesin family member 9 PTPN23 3p21.3 protein tyrosine phosphatase, non-receptor type 23 SCAP 3p24.3-p22.1 protein tyrosine phosphatase, non-receptor type 23 FLJ20211 3p21.31 hypothetical protein FLJ20211 CSPG5 3p21.3 chondroitin sulfate proteoglycan 5 (neuroglycan C) SMARCC1 3p23-p21 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 DHX30 3p31.31 DEAH (Asp-Glu-Ala-His) box polypeptide 30 MAP4 3p21.3 microtubule-associated protein 4 LOC391536 3 similar to 60S ribosomal protein L17 (L23) CDC25A 3p21.3 cell division cycle 25A CAMP 3p21.3 cathelicidin antimicrobial peptide SZF1 3p21 KRAB-zinc finger protein SZF1-1 MRPS18AP1 3p21.31 mitochondrial ribosomal protein S18A pseudogene 1 NME6 3p21.3 non-metastatic cells 6, protein expressed in (nucleoside-diphosphate kinase)
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticthymus   highly
Cardiovascularheart   highly
Digestiveliver    
Respiratorylung   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
Muscularstriatumcardiac  
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text muscle
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
three EF-hand domains
secondary structure two heavy chains and four light chains
mono polymer hexamer
HOMOLOGY
interspecies homolog to murine Mylc
Homologene
FAMILY
CATEGORY motor/contractile , structural protein
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytoskeleton
basic FUNCTION modulating the interaction between myosin and actin
CELLULAR PROCESS
PHYSIOLOGICAL PROCESS cardiovascular
PATHWAY
metabolism
signaling
a component myosin is an hexamer of 2 heavy chains and 4 light chains
INTERACTION
DNA
RNA
small molecule
protein CASP3 (cleavage of MYL3 contributing to depression of myocyte function)
cell & other
REGULATION
ASSOCIATED DISORDERS
corresponding disease(s) CMH8
related resource FHC Mutation Database
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
ANIMAL & CELL MODELS