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FLASH GENE
Symbol MYH4 contributors: mct/npt - updated : 30-09-2014
HGNC name myosin, heavy polypeptide 4, skeletal muscle
HGNC id 7574
Location 17p13.1      Physical location : 10.346.609 - 10.372.876
Synonym name
  • myosin heavy chain 4
  • myosin heavy chain 2b
  • myosin heavy chain, skeletal muscle, fetal
    • Synonym symbol(s) MYH2B, MyHC-2B, MyHC-IIb
    DNA
    TYPE functioning gene
    STRUCTURE 26.27 kb     40 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    40 - 6016 - 1939 - Weiss (1999)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Respiratoryrespiratory tractlarynx    Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularsmoothmyoepithelium highly Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • globular head associating to the light chain
  • actin and ATP binding sites
  • a neck containing IQ calmodulin or calmodulin-like light chain binding domain (the converter) connected to the base of a long alpha helical tail,(the liver)
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • motor contractile protein moving towards the "plus" end of actin track
  • constitute the actomyosin cytoskeleton that mediates contractility during apoptosis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • only uses NFATC4 (Calabria 2009)
  • MSTN positively regulates slow isoform MYH7 but negatively regulates fast isoforms MYH1, MYH4
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • ariel mouse suffers from a fulminant myofibrillar myopathy, due to the rapid accumulation of large intracellular protein aggregates, caused by an ENU-induced recessive mutation resulting in an L342Q change within the motor domain of the skeletal muscle myosin protein Myh4