Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol MYH15 contributors: mct - updated : 24-03-2020
HGNC name myosin, heavy chain 15
HGNC id 31073
Location 3q13.13      Physical location : 108.099.215 - 108.248.169
Synonym name
  • related to chicken myosin heavy chain
  • myosin, heavy polypeptide 15
  • myosin-15
  • Synonym symbol(s) KIAA1000
    DNA
    TYPE functioning gene
    STRUCTURE 169.10 kb     42 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    42 - 7075 224 1946 - 2007 18073581
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineneuroendocrinepituitary    Homo sapiens
    Reproductivemale systemtestis    Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscular    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION
    text
  • detected after birth in the orbital layer of extraocular (EO) muscles
  • MYH7B and MYH15, are expressed in muscle spindles
  • basic FUNCTION
  • motor activity
  • MYH7B and MYH15 play a prominent role in the heart and skeletal muscles of certain species like chicken and snakes, whereas in mammals, the only muscles that these myosin motors function in are highly specialized muscles
  • acts as a conventional sarcomeric myosin
  • could retain a contractile or motile role outside of a muscle cell
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to Amyotrophic lateral sclerosis (ALS)
    Variant & Polymorphism other
  • rare variants in MYH15 represent a likely genetic risk factor for ALS
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS