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FLASH GENE
Symbol MYH14 contributors: mct - updated : 31-05-2016
HGNC name myosin, heavy polypeptide 14
HGNC id 23212
Corresponding disease
DFNA4 neurosensory deafness 4
PNMHH peripheral neuropathy, myopathy, hoarseness, and hearing loss
Location 19q13.33      Physical location : 50.706.884 - 50.813.801
Synonym name
  • nonmuscle myosin heavy chain II-C
  • myosin 2C
  • Synonym symbol(s) FLJ13881, KIAA2034, NHMCII, NMHC-II-C, FP17425, DFNA4, DKFZp667A1311, FLJ43092, MHC16
    EC.number 3.6.4.1
    DNA
    TYPE functioning gene
    STRUCTURE 106.92 kb     43 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    RRAS 19q13.3-q13.4 related RAS viral (r-ras) oncogene homolog SR-A1 19q13.3-q13.4 serine arginine-rich pre-mRNA splicing factor SR-A1 IRF3 19q13.3 interferon regulatory factor 3 BCL2L12 19q13.3 BCL2-like 12 (proline rich) HRMT1L2 19q13-3 HMT1 hnRNP methyltransferase-like 2 (S. cerevisiae) LOC199800 19q13.33 hypothetical protein LOC199800 CPT1C 19q13.33 hypothetical protein LOC199800 LOC388556 19 hypothetical gene supported by NM_001013 TSKS 19q13.3 hypothetical gene supported by NM_001013 AP2A1 19q13.3 adaptor-related protein complex 2, alpha 1 subunit FLJ22688 19q13.33 hypothetical protein FLJ22688 TCBAP0758 19q13.3 hypothetical protein TCBAP0758 PTOV1 19q13.33 prostate tumor over expressed gene 1 PNKP 19q13.3-q13.4 polynucleotide kinase 3'-phosphatase MGC2865 19q13.33 hypothetical protein MGC2865 FLJ12168 IL4I1 19q13.3-q13.4 interleukin 4 induced 1 NUP62 19q13.33 nucleoporin 62kDa ATF5 19q13.3 activating transcription factor 5 SIGLEC11 19q13.33 sialic acid binding Ig-like lectin 11 VRK3 19q13 vaccinia related kinase 3 ZNF473 19q13.33 zinc finger protein 473 LOC342917 19q13.33 similar to kruppel-related zinc finger protein MGC33947 19q13.33 hypothetical protein MGC33947 MYH14 19q13.33 myosin, heavy polypeptide 14 KCNC3 19q13.3 potassium voltage-gated channel, Shaw-related subfamily, member 3 NAP1L 19q13.33 potassium voltage-gated channel, Shaw-related subfamily, member 3 NAP1 19q13.33 pronapsin A NR1H2 19q13.3 nuclear receptor subfamily 1, group H, member 2 POLD1 19q13.3 polymerase (DNA directed), delta 1, catalytic subunit 125kDa SPIB 19q13.3 Spi-B transcription factor (Spi-1/PU.1 related) MYBPC2 19q13.3 myosin binding protein C, fast type LOC284361 19q13.33-q13.41 hypothetical protein LOC284361 SBBI54 19q13.41 hypothetical transmembrane protein SBBI54 LOC284363 19q13.41 similar to RIKEN cDNA 0610012D14 DKFZp761A179
    RNA
    TRANSCRIPTS type messenger
    text two splice variants
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    43 - 6930 - 2036 - 2009 19240025
    42 - 6831 - 2003 - 2009 19240025
    41 - 6807 - 1995 - 2009 19240025
    - - 650 - - expressed only in neuronal tissue 2009 19240025
  • NM II-C2, that is generated by alternative splicing of an exon, C2, encoding 33 AAs
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon highly
     mouthtongue  highly
    Hearing/EquilibriumearinnercochleaCorti  Homo sapiens
    Nervousbrain    
     nervespinal nervesciatic  
    Respiratoryrespiratory tractlarynx  highly
    Skin/Tegumentskin appendageshairfollicle  
    Visualeyeretina   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Hearing / Equilibriumcochlea cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text embryonic cartilage
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal myosin domain
  • a myosin-like globular head domain
  • two Iq domains
  • positively charged region of the non-helical tailpiece promotes filament assembly
  • a C terminal myosin tail
  • mono polymer homomer , dimer , hexamer
    HOMOLOGY
    intraspecies homolog to MYH10, MYH9, MYH11
    Homologene
    FAMILY non muscle myosin heavy chain family (myosin II family)
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    basic FUNCTION
  • cellular myosin playing a role in cytokinesis, cell shape, and specialized functions such as secretion and capping
  • with MYH9, modulates neuronal cell adhesion (
  • with MYH10 was found to be critical for driving neuronal process outgrowth
  • nonsarcomeric conventional myosin motor, that must participate in distinctive cellular roles and reinforces our view that closely related motor isoforms drive diverse functions within neuronal cells
  • directly regulates cellular patterning and alignment within the cochlear sensory epithelium
  • MYH9, MYH10, MYH14 are involved in regulating cardiac myocyte karyokinesis by affecting microtubule dynamics
  • MYH9, MYH10, MYH14 are a group of molecular motors involved in a wide variety of cellular processes including cytokinesis, migration, and control of cell morphology
  • although MYH9 and MYH10 form filaments with similar properties, MYH14 forms filaments that are less well suited to roles such as tension maintenance within the cell
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
    ATP binding
    protein
  • interacting with cytoskeletal actin in absence of ATP
  • SDCCAG8 interacts with proteins of the centriolar satellites (OFD1, CEP131), of the endosomal sorting complex (RABEP2, ERC1), and with non-muscle myosin motor proteins (MYH9, MYH10, MYH14) at the centrosome
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DFNA4 , PNMHH
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS