Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol MYH10 contributors: mct - updated : 26-03-2020
HGNC name myosin, heavy polypeptide 10, non-muscle
HGNC id 7568
Location 17p13.1      Physical location : 8.377.531 - 8.534.036
Synonym name
  • cellular myosin heavy chain, type B
  • myosin 2B
  • Synonym symbol(s) NMHC-B, NMHC-II-B, NMMHCB, MGC134913, MGC134914
    DNA
    TYPE functioning gene
    STRUCTURE 157.16 kb     41 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    41 - 7619 - 1976 - 2019 31486768
    42 - 7712 - 1985 - 2019 31486768
    43 - 7778 235 2007 - 2019 31486768
    41 - 7656 - 1986 - 2019 31486768
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Hearing/Equilibriumearinnercochlea   Homo sapiens
    Nervousbrain     Homo sapiens
     brainforebraincerebral cortex   Homo sapiensFetal
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmegakaryocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • globular head associating to the light chain and containing actin and ATP binding sites
  • a neck containing IQ calmodulin or calmodulin-like light chain binding domain (the converter) connected to the base of a long alpha helical tail,(the liver)
  • C-terminal region of the myosin heavy chain supersedes the distinct motor properties of MYH9 and MYH10 as the predominant factor directing isoform-specific distribution
  • HOMOLOGY
    Homologene
    FAMILY non muscle myosin heavy chain family (myosin II family)
    CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus
    text
  • localizes at the cleavage furrow of megacaryocytes
  • basic FUNCTION
  • motor contractile protein moving towards the "plus" end of actin track
  • myosins IIA and IIB (MYH9 and MYH10), participate in neuronal adhesion, outgrowth and retraction (
  • with MYH14 was found to be critical for driving neuronal process outgrowth
  • directly regulates cellular patterning and alignment within the cochlear sensory epithelium
  • possible role in maintaining the integrity of intercalated discs
  • potentially promotes TNF cell death signaling in a manner independent of its force generating property
  • possible role in TNFR1 endocytosis and the formation of the death inducing signaling complex (DISC)
  • regulates actin dynamics during synaptic plasticity and memory formation
  • MYH9, MYH10, MYH14 are involved in regulating cardiac myocyte karyokinesis by affecting microtubule dynamics
  • MYH7B and MYH10 have distinct and overlapping effects on spine morphology
  • is involved in the enucleation of human erythroblasts
  • plays an essential and non-redundant role in cytokinesis during meiotic cell divisions of the male germline
  • acts as a regulator of multiple steps of cortical neuron migration and morphogenesis in the developing cortex
  • MYH9, MYH10, MYH14 are a group of molecular motors involved in a wide variety of cellular processes including cytokinesis, migration, and control of cell morphology
  • although MYH9 and MYH10 form filaments with similar properties, MYH14 forms filaments that are less well suited to roles such as tension maintenance within the cell
  • mediate centrosome reorientation during cell migration
  • is required for centriole migration to the apical plasma membrane, which occurs at the onset of ciliogenesis
  • is a key molecular factor that guides input-specific circuit maturation in the developing hippocampus
  • plays a major role in applying force on the nucleus to facilitate nuclear translocation through tight spaces 0)
  • MYH10 is essential for cardiac myocyte cytokinesis
  • required in epicardial formation and functions to support myocardial proliferation and coronary vessel development
  • regulates epicardial integrity and epicardium-derived mesenchymal cell maturation
  • role for MYH9 and MYH10 as negative regulators of proliferation in the mammary epithelium
  • requirement for MYH10 in epicardial function and coronary vessel formation, highlighting the importance of this protein in cardiac development and ultimately, embryonic survival
  • MYH9 plays a role in steering migration by maintaining stable protrusions in the anterior region, whereas MYH10 plays a role in maintenance of front-rear polarity by preventing aberrant protrusion formation in the posterior region
  • critical roles for MYH10 in alveologenesis at least in part via the regulation of ECM remodeling, which may contribute to the pathogenesis of emphysema
  • complementary functions of MYH9, MYH10 in the biogenesis and integrity of Adherens junction (AJ)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • functional and physical interaction between CLN3 and myosin-IIB (MYH10)
  • EMD functions with MYH10 to polarize actin flow and nuclear movement in fibroblasts, suggesting a novel function for the nuclear envelope in organizing directional actin flow and cytoplasmic polarity
  • MYH10 influences centrosomal recruitment of IFT88, which is required for the transport of building blocks to the ciliary tip
  • SDCCAG8 interacts with proteins of the centriolar satellites (OFD1, CEP131), of the endosomal sorting complex (RABEP2, ERC1), and with non-muscle myosin motor proteins (MYH9, MYH10, MYH14) at the centrosome
  • cytokinesis failure in megakaryocytes is the consequence of both the absence of MYH10 and a low RHOA activity that impairs MYH9 localization at the cleavage furrow through increased actin turnover
  • subcellular localization and function of MYH10 are regulated by its binding partner, filamin-A interacting protein (FILIP1)
  • inhibition of ATPase activity of HSPA8 impaired the effect of FILIP1 on the subcellular distribution of MYH10
  • is involved in CDH1 clustering, maintenance of a branched actin layer connecting CDH1 complexes and perijunctional actin fibres leading to the building-up of anisotropic stress
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in the lung of emphysema patients
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • absence of NMII-B in cardiac myocytes in mice results in cardiomyopathy in the adult heart