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FLASH GENE
Symbol MYF6 contributors: mct - updated : 23-08-2011
HGNC name myogenic factor 6 (herculin)
HGNC id 7566
Location 12q21      Physical location : 81.101.407 - 81.103.254
Synonym name
  • Becker muscular dystrophy modifier
  • muscle regulatory factor 4
  • Synonym symbol(s) MRF4, HERCULIN
    DNA
    TYPE functioning gene
    STRUCTURE 1.00 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map see MYF5
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text mostly in proliferating myoblasts (in mice)
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • basic helix-loop-helix (HLH) protein
  • myogenic basic domain
  • mono polymer homomer , heteromer , dimer
    HOMOLOGY
    interspecies homolog to rattus Myf6 (95,5 pc)
    homolog to murine Myf6 (95,5 pc)
    homolog to chicken MYF6 (82,6 pc)
    Homologene
    FAMILY
  • myogenic b(hlh) family of transcription factors
  • MEF1 subfamily
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • involved in the terminal steps of the muscle differentiation
  • CELLULAR PROCESS cell life, differentiation
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimerizing with E2A and binding DNA cooperatively with PBXs/MEISs/PKNOX1
  • also forming heterodimers with OTF2 and others
  • INTERACTION
    DNA binding to E-box motifs d(CANNTG)
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation      
    potential aggravating effect in a patient with BMD
    Susceptibility
    Variant & Polymorphism SNP
  • A90D in centronuclear myopathy
  • A112S in centronuclear myopathy
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS