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FLASH GENE
Symbol MYCL1 contributors: mct - updated : 20-03-2012
HGNC name v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian)
HGNC id 7555
Location 1p34.2      Physical location : 40.361.095 - 40.367.687
Synonym name
  • l-myc-1 proto-oncogene
  • myc-related gene from lung cancer
  • class E basic helix-loop-helix protein 38
    • Synonym symbol(s) LMYC, MYCL, bHLHe38
    DNA
    TYPE functioning gene
    STRUCTURE 6.59 kb     3 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked Y status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 splicing polyA site 3624 39.2 364 - Kaye
    3 splicing polyA site 3260 - 394 - Kaye, Kambara
    2 - 2050 - 236 - -
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Nervousbrain   moderately
    Respiratoryrespiratory tractlarynx   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    		basic helix-loop-helix (HLH), leucine zipper domains
    mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to avian myelocytomatosis viral (v-myc) oncogene 1
    ortholog to murine Lmyc1
    homolog to C.elegans Y75B8A.28
    Homologene
    FAMILY
  • basic helix-loop-helix (BHLH) family of transcription factors
  • BHLH-ZIP subfamily
    • CATEGORY transcription factor , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • as well as MYC mutants (W136E and dN2), all of which have little transformation activity, promoted human induced pluripotent stem cells (iPSC) generation more efficiently and specifically compared with MYC
    • CELLULAR PROCESS cell life, proliferation/growth
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component heterodimerizing with MAX
    INTERACTION
    DNA binds DNA as an
    heterodimer with MAX
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   LOH    
    in colorectal tumor with poor prognosis
    tumoral   amplification    
    in Merkel cell carcinoma
    Susceptibility to head and neck nonmelanoma skin (HNNMSC)
    Variant & Polymorphism other
  • SS genotype was found to correlate with aggressive tumor behavior in patients with HNNMSC and a family history of cancer
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS