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FLASH GENE
Symbol MYCBP contributors: mct - updated : 17-11-2017
HGNC name c-myc binding protein
HGNC id 7554
Location 1p33-p32.2      Physical location : 39.328.636 - 39.339.050
Synonym name associate of MYC-1
Synonym symbol(s) AMY1, AMY-1, MBP-1
DNA
TYPE functioning gene
STRUCTURE 10.00 kb     5 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 2093 - 103 - Sedoris (2007)
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivefemale systemplacenta  highly
 male systemtestis  highly
Urinarybladder   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal region involved in all the biologic functions of MYC
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus
    text
  • mostly expressed in the cytoplasm translocating into the nucleus for c-myc (MYC) expression
  • localizes to the trans-Golgi network (TGN)
  • basic FUNCTION
  • stimulating the activation of the E-box regulated transcription by MYC/MAX
  • playing roles in spermatogenesis
  • may play a central role in regulating the abnormal proliferative characteristics of transformed cells
  • playing an important role in the altered cell proliferation and energy utilization that occur in response to an altered glucose concentration
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • MYCBP forms a complex with GLI and SUFU without HH stimulation but remains inactive
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • c-myc binding, interacting with the N terminal transactivation domain of MYC
  • with MYCBPAP
  • binding to the N-terminal half of AKAP1 in a quaternary complex with C3orf15 and a regulatory subunit (RII) of cAMP-dependent kinase (PKA)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS