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FLASH GENE
Symbol MYBPH contributors: mct - updated : 21-05-2012
HGNC name myosin binding protein H
HGNC id 7552
Location 1q32.1      Physical location : 203.136.938 - 203.144.942
DNA
TYPE anonymous DNA segment
STRUCTURE 8.01 kb     11 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LGR6 1q32.1 leucine-rich repeat-containing G protein-coupled receptor 6 HSPC150 1q32.1 HSPC150 protein similar to ubiquitin-conjugating enzyme PPP1R12B 1q32.1 protein phosphatase 1, regulatory (inhibitor) subunit 12B HCP4 1q32.1 cytochrome c, somatic pseudogene SYT2 1q31.3 synaptotagmin II PLU-1 1q32.1 putative DNA/chromatin binding motif LOC388727 1 LOC388727 LOC163556 1q32.1 similar to RIKEN cDNA 4931440L10 LOC391152 1 similar to Tubulin alpha-2 chain (Alpha-tubulin 2) LOC388728 1 similar to alpha tubulin LOC391153 1 similar to actin RABIF 1q32-q41 RAB interacting factor C3IP1 1q32.1 kelch-like protein C3IP1 ADIPOR1 1p36.13-q41 adiponectin receptor 1 CYB5R1 1p36.13-q41 cytochrome b5 reductase 1 (B5R.1) LOC391154 1 similar to hypothetical protein 4933406M09 C1orf37 1q31.1 chromosome 1 open reading frame 37 PPFIA4 1q32.1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 MYOG 1q31-q41 myogenin (myogenic factor 4) ADORA1 1q32.1 adenosine A1 receptor MYBPH 1q32.1 myosin binding protein H CHI3L1 1q31-q32 chitinase 3-like 1 (cartilage glycoprotein-39) CHIT1 1q31-q32 chitinase 1 (chitotriosidase) LOC388729 1 LOC388729 BTG2 1q32 BTG family, member 2 FMOD 1q32.1 fibromodulin ATP2B4 1q32 ATPase, Ca++ transporting, plasma membrane 4 MGC5457 1q32.1 hypothetical protein MGC5457 LAX 1q32.1 hypothetical protein FLJ20340 KIAA0663 1q32.1 hypothetical protein FLJ20340 SNRPE 1q32 small nuclear ribonucleoprotein polypeptide E LOC391155 1 similar to KRT8 protein FLJ40343 1q32.1 hypothetical protein FLJ40343 SOX13 1q31.3-q32.1 SRY (sex determining region Y)-box 13 FLJ10761 1q32.1 putative ethanolamine kinase REN 1q32 renin KISS1 1q32 KiSS-1 metastasis-suppressor FLJ42654 1q32.1 FLJ42654 protein
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 1806 - 477 - 1994 7881442
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestivemouthtongue   
Endocrineparathyroid    
Reproductivemale systemprostate  moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two immunoglobulin-like C2-type domains
  • two fibronectin type III domains, and one fibronectin type III domain was required for MYBPH binding to MYH9
  • HOMOLOGY
    interspecies ortholog to murine Mybph
    homolog to rattus Mybph
    homolog to zebrafish Dr.7502
    homolog to C.elegans T06D4.1
    Homologene
    FAMILY
  • immunoglobulin superfamily, MYBP subfamily
  • CATEGORY adhesion , motor/contractile , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • involved in the regulation of striated muscle contraction
  • may be involved in interaction with thick myofilaments in the a-band
  • MYBPH is a transcriptional target of the TTF1 lineage-survival oncogene and plays a crucial role in inhibition of cancer cell motility, invasion, and metastasis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text
  • muscle development
  • structural constituent of muscle
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to myosin and to thick myofilaments in the A-band
  • MYBPH directly interacts with an additional molecule, MYH9, which was found to occur between MYBPH and the rod portion of MYH9
  • MYBPH inhibited MYH9 assembly and reduced cell motility
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS