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FLASH GENE
Symbol MYBL2 contributors: mct - updated : 09-11-2013
HGNC name v-myb myeloblastosis viral oncogene homolog (avian)-like 2
HGNC id 7548
Location 20q13.12      Physical location : 42.295.708 - 42.345.122
Synonym symbol(s) BMYB, B-MYB
DNA
TYPE functioning gene
STRUCTURE 49.41 kb     14 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Physical map
PPIAL 20q12 peptidylprolyl isomerase A (cyclophilin A)-like SFRS6 20q13.1 splicing factor, arginine/serine-rich 6 L3MBTL 20q13.12 l(3)mbt-like (Drosophila) SGK2 20q13.2 serum/glucocorticoid regulated kinase 2 C20orf9 20q12-q13.1 chromosome 20 open reading frame 9 RPL27AP 20q13.11 ribosomal protein L27a pseudogene MYBL2 20q13.1 v-myb myeloblastosis viral oncogene homolog (avian)-like 2 C20orf65 20q13.11 chromosome 20 open reading frame 65 C20orf100 20q13.11 chromosome 20 open reading frame 100 JPH2 20q12-q13.1 junctophilin 2 C20orf111 20q13.11 chromosome 20 open reading frame 111 GDAP1L1 20q12 ganglioside-induced differentiation-associated protein 1-like 1 C20orf142 20q13.12 chromosome 20 open reading frame 142 R3HDML 20 R3H domain (binds single-stranded nucleic acids) containing-like FLJ39654 20q13.12 hypothetical protein FLJ39654 LOC149704 20q13.12 hypothetical LOC149704 HNF4A 20q12-q13.1 hepatocyte nuclear factor 4, alpha RPL37AP1 20q12 ribosomal protein L37a pseudogene 1 C20orf121 20q13.11 chromosome 20 open reading frame 121
regionally located located in a region commonly deleted in myeloid disorders
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
14 - 2731 - 700 - 2011 21148321
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   highly
Endocrinepancreas   highly
Lymphoid/Immunelymph node   moderately
 tonsils   predominantly
Nervousbrain    
Reproductivefemale systemuteruscervix moderately
 female systemovary  moderately
 male systemprostate  highly
Respiratorylung   highly
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Lymphoid    
cell lineage
cell lines
fluid/secretion highly in lymph
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three MYB-like domains
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to rattus Mybl2 (88.5 pc)
    homolog to murine Mybl2 (85.8 pc)
    Homologene
    FAMILY oncoprotein myb family
    CATEGORY transcription factor , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • involved in the regulation of cell survival, proliferation, and differentiation
  • transactivating the expression of the CLU gene
  • acting as a negative regulator of vascular smooth muscle cell matrix gene transcription
  • elevates endogenous ADORA2B mRNA and receptor activity, and this activity decreases cell proliferation
  • transcription factor belonging to the MYB family that is frequently overexpressed or amplified in different types of human malignancies
  • nuclear transcription factor involved in cell-cycle progression
  • enhances STRAP-mediated inhibition of TGFB signaling pathways, such as apoptosis and growth inhibition, by modulating complex formation between the TGFB receptor and SMAD3 or SMAD7
  • acts as a positive regulator of STRAP
  • plays potentially a subtle but key role in linking specific aspects of cell-cycle progression with generation of signals for differentiation and may therefore be fundamental in commitment of intestinal epithelial cells to differentiation pathways during their maturation
  • LIN9 and MYBL2 were both required for transcription of G(2)/M genes such as CCCNB1 and Survivin
  • novel role for MYBL2 in S-phase that appears to be independent of its sequence-specific DNA-binding activity and its ability to stimulate the expression of bona fide MYBL2 target genes
  • CELLULAR PROCESS cell cycle, progression
    cell life, antiapoptosis
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • ZNF622
  • is required as a pioneer factor to enable FOXM1 binding to G2/M gene promoters
  • KCTD13 is able to interact with MYBL2 and PCNA simultaneously
  • CCNF interacts with MYBL2 via the cyclin box domain and this interaction is important to suppress CCNA-mediated phosphorylation of MYBL2, a key step in MYBL2 activation
  • cell & other
    REGULATION
    repressed by MORF4L2
    Other phosphorylated at Thr-520 by cyclin A/CDK2 during S-phase
    expression regulated at the G1/S phase transition
    regulated by temperature
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       gain of function
    in hepatocellular carcinoma, induces fast growth and progression of premalignant and malignant liver, through cell cycle deregulation and activation of genes and pathways related to tumor progression
    tumoral     --over  
    is associated with a poor prognosis in neuroblastoma
    Susceptibility to neoplastic disease
    Variant & Polymorphism other
  • alleles that might be associated with a reduced risk of developing neoplastic disease
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    treatment of patients with agents that inhibit MYBL2 may be effective as adjuvant therapy
    ANIMAL & CELL MODELS