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FLASH GENE
Symbol MYBBP1A contributors: mct - updated : 02/12/2008
HGNC name MYB binding protein (P160) 1a
HGNC id 7546
Location 17p13.2      Physical location : 4.442.191 - 4.458.681
Synonym name
  • p53-activated protein-2
  • MYB binding protein 1a
    • Synonym symbol(s) P160, PAP2, FLJ37886
    DNA
    TYPE functioning gene
    STRUCTURE 16.49 kb     28 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Map pter - D17S34 - D17S849 - D17S695 - D17S926 - D17S5 - D17S379 - D17S1828 - [D17S861E - ALOX15 ] - D17S938 - cen
    Authors Keough (99)
    Text [MYBBP1A ]
    Physical map
    MGC32124 17p13.3 hypothetical protein MGC32124 ANKFY1 17p13.3 ankyrin repeat and FYVE domain containing 1 UBE2G1 1q42 ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, C. elegans) MGC29671 17p13.3 hypothetical protein MGC29671 LOC124976 17p13.3 hypothetical protein LOC124976 MYBBP1A 17p13.3 MYB binding protein (P160) 1a FLJ90165 17p13.3 hypothetical protein FLJ90165 LOC124974 17p13.3 thioredoxin 1 pseudogene 4 FLJ42461 17p13.3 FLJ42461 protein ALOX15 17p13.1 arachidonate 15-lipoxygenase PELP1 17p13.3 arachidonate 15-lipoxygenase LOC390758 17 similar to 40S RIBOSOMAL PROTEIN S12 ARRB2 17p13 arrestin, beta 2 CXCL16 17p13 chemokine (C-X-C motif) ligand 16 LOC388322 17 similar to HSPC296 ZMYND15 17p13.3 zinc finger, MYND domain containing 15 TM4SF5 17p13.3 transmembrane 4 superfamily member 5 LOC284013 17p13.3 secretory protein LOC284013 LOC388323 17 similar to RIKEN cDNA C730027E14 PSMB6 17p13 proteasome (prosome, macropain) subunit, beta type, 6 PLD2 17p13.1 phospholipase D2 LOC284015 17p13.3 similar to Vacuolar ATP synthase 16 kDa proteolipid subunit MINK 17p13 similar to Vacuolar ATP synthase 16 kDa proteolipid subunit CHRNE 17p13.1 cholinergic receptor, nicotinic, epsilon polypeptide GP1BA 17pter-p12 glycoprotein Ib (platelet), alpha polypeptide SLC25A11 17p13.3 solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11 DKFZP566H073 17p13.3 DKFZP566H073 protein PFN1 17p13.3 profilin 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    27 - 4122 149.2 1332 - Keough (1999)
  • isoform 1
    • 26 - 4585 148.7 1328 - Keough (1999)
  • isoform 2
  • a central acidic region
  • C-terminal basic amino acid repeats
  • a number of potential leucine charged domain motifs
    		•
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon  
    Endocrinepancreas    
    Lymphoid/Immunespleen   highly
    Nervousbrain    
    Reproductivefemale systemuteruscervix moderately
     male systemprostate   
    Respiratoryrespiratory tractlarynx  moderately
    Skin/Tegumentskin   moderately
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    cell lineage
    cell lines
    fluid/secretion highly in lymph
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to rattus Mybbp1a (69.9 pc)
    homolog to murine Mybbp1a (71.3 pc)
    Homologene
    FAMILY
    CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,nucleolus
    text
  • predominantly nucleolar
  • shuttling between the nucleus and cytoplasm
  • nuclear import may be mediated by KPNA2, while export appears to depend partially on XPO1/CRM1
  • when rRNA transcription was suppressed by nucleolar stress, MYBBP1A translocated to the nucleoplasm and facilitated TP53-EP300 interaction to enhance TP53 acetylation
    • basic FUNCTION
  • may activate or repress transcription via interactions with sequence specific DNA-binding proteins
  • repressing JUN, MYB and PPARGC1A
  • stimulating transcription by AHR
  • may function to regulate cell type specific genes
  • novel substrate of AURKB and may be involved in mitosis (Perrera 2010)
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • binding to JUN and MYB via the leucine zipper regions present in these proteins
  • binding to PPARGC1A
  • binding to AHR
  • binding to KPNA2
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS