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FLASH GENE
Symbol MYADM contributors: shn/mct - updated : 29-04-2015
HGNC name myeloid-associated differentiation marker
HGNC id 7544
Location 19q13.42      Physical location : 54.369.610 - 54.379.682
Synonym name
  • myeloid upregulated protein
  • Synonym symbol(s) UNQ553/PRO1110, SB135
    DNA
    TYPE functioning gene
    STRUCTURE 10.85 kb     3 Exon(s)
    MAPPING cloned Y linked N status provisional
    Map cen - D19S924 - D19S927 - MYADM - D19S926 - D19S418 - qter
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 splicing 3243 - 322 - 2001 12075932
    3 splicing 3077 - 322 - 2001 12075932
    3 splicing 3141 - 322 - 2001 12075932
    3 splicing 3077 - 322 - 2001 12075932
    3 splicing 3209 - 322 - 2001 12075932
    3 - 3161 - 322 - 2001 12075932
    3 - 3340 - 322 - 2001 12075932
    3 - 3100 - 322 - 2001 12075932
    3 - 3083 - 322 - 2001 12075932
    2 - 3010 - 322 - 2001 12075932
    3 - 3131 - 322 - 2001 12075932
    3 - 3610 - 322 - 2001 12075932
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvessel     Homo sapiens
    Nervousbrain   lowly Homo sapiens
    Reproductivemale systemprostate   
    Respiratorylung   moderately Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
     bone marrow  lowly Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmonocyte Homo sapiensmRNA
    Cardiovascularendothelial cell Homo sapiens
    Endocrineislet cell (alpha,beta...)
    Lymphoid/Immunedendritic cell Homo sapiensmRNA
    cell lineage FDCP-mix cells, myeloid progenitor 32D, myeloid bone marrow, macrophage P388, macrophage J774 (
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • eight putative transmembrane segments
  • one MARVEL domain
  • HOMOLOGY
    interspecies ortholog to Myadm, Mus musculus
    ortholog to Myadm, Rattusz norvegicus
    Homologene
    FAMILY MAL family
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    basic FUNCTION
  • associated with the differentiation of hematopoietic cells or leukemia cells
  • involved in the myeloid differentiation process, indicating that MYADM may be one useful membrane marker to monitor stem cell differentiation or myeloid leukemia differentiation
  • important for the organization of membrane domains crucial for appropriate targeting of Rac1 and hence for lamellipodium extension and cell motility
  • in epithelial cells, the MAL family members MAL, MAL2, and MYADM regulate the function and dynamics of ordered membrane domains
  • regulates the connection between the plasma membrane and the cortical cytoskeleton and so can control the endothelial inflammatory response
  • CELLULAR PROCESS cell life, differentiation
    cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by all-trans retinoic acid (ATRA)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • MYADM knockdown (KD) cells had altered membrane condensation and showed deficient incorporation of Rac1 to membrane raft fractions and exhibited reduced cell spreading and migration (