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FLASH GENE
Symbol MXD4 contributors: npt/ - updated : 07-05-2004
HGNC name MAX dimerization protein 4
HGNC id 13906
Location 4p16.3      Physical location : 2.249.159 - 2.263.739
Synonym name
  • Max-associated protein 4
  • Max-interacting transcriptional repressor MAD4
  • Synonym symbol(s) MAD4, MSTP149, MST149, bHLHc12
    DNA
    TYPE functioning gene
    STRUCTURE 14.58 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 3773 23.4 209 - -
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine Mad4
    Homologene
    FAMILY
  • MAD family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • compete for MAX binding with MYC, in the transcriptional activation complex, leading to repression of transcription
  • may be tumor suppressor gene, contributing to the regulation of cell growth in differentiating tissues
  • CELLULAR PROCESS cell life, proliferation/growth
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • heterodimerizing with MAX to form a transcriptional repressor complex
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS