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FLASH GENE

Symbol

MXD3

contributors: mct/npt - updated : 06-04-2010

HGNC name	MAX dimerization protein 3
HGNC id	14008

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	5q35.3      Physical location : 176.732.500 - 176.739.292
Synonym name	Max-interacting transcriptional repressor MAD3
	Max-associated protein 3
	class C basic helix-loop-helix protein 13
Synonym symbol(s)	MAD3, MGC2383, Myx, bHLHc13, FLJ35523

DNA

TYPE	functioning gene
STRUCTURE	6.80 kb     6 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001142935 6 - 2662 NP_001136407 - 193 - Yun (2007) NM_031300 6 - 1483 NP_112590 - 206 - Yun (2007)

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Respiratory lung

cell lineage

cell lines

fluid/secretion

at STAGE

cell cycle

cell cycle, S

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

one helix-loop-helix domain

mono polymer

heteromer , dimer

HOMOLOGY

interspecies

ortholog to murine Mxd3 (85 pc)

Homologene

FAMILY	bHLH family of transcription factor
	MAD family

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus
text	expressed specifically during the S-phase of the cell cycle in both proliferating and differentiating cells (Fox 2003)

basic FUNCTION	represses transcription, when bound to MAX protein
	necessary role for SHH-dependent granule neuron precursors proliferation (Yun 2007)
	should antagonize MYCN by competition for direct DNA binding via Max dimerization (Yun 2007)
	may be having a role in cellular proliferation and tumorigenesis (Barisone 2008)
	promotes the segregation of nonexchange chromosomes that are not tethered by SLC39A1 at their centromeresb (Newnhan 2010)
	negatively regulates B cell differentiation in the spleen by inducing ID2 expression

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

binding

RNA

small molecule

protein	interacting with MAX
	interacts with other DNA binding proteins to repress transcription (Yun 2007)
	transcriptional target of E2F1 (Fox 2003)

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS