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FLASH GENE
Symbol MXD3 contributors: mct/npt - updated : 06-04-2010
HGNC name MAX dimerization protein 3
HGNC id 14008
Location 5q35.3      Physical location : 176.732.500 - 176.739.292
Synonym name
  • Max-interacting transcriptional repressor MAD3
  • Max-associated protein 3
  • class C basic helix-loop-helix protein 13
  • Synonym symbol(s) MAD3, MGC2383, Myx, bHLHc13, FLJ35523
    DNA
    TYPE functioning gene
    STRUCTURE 6.80 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    RNF44 5q35.3 ring finger protein 44 PC-LKC 5q35.3 protocadherin LKC KIAA1893 5q35.3 G protein-regulated inducer of neurite outgrowth 1 SNCB 5q35 synuclein, beta LOC253314 5q35.3 similar to eukaryotic translation initiation factor eIF4E-1 MGC14859 5q35.3 hypothetical protein MGC14859 LOC389348 5 LOC389348 KIAA1976 5q35.3 netrin receptor Unc5h1 HK3 5q35.2-q35.3 hexokinase 3 (white cell) RAP80 5q35.3 receptor associated protein 80 JAZ 5q35.3 double-stranded RNA-binding zinc finger protein JAZ FGFR4 5q35.3 fibroblast growth factor receptor 4 NSD1 5q35.1-q35.3 nuclear receptor binding SET domain protein 1 RAB24 5q35.3 RAB24, member RAS oncogene family PX19 5q35.3 px19-like protein MXD3 5q35.3 MAX dimerization protein 3 LMAN2 5q35 lectin, mannose-binding 2 RGS14 5q35.3 regulator of G-protein signalling 14 SLC34A1 5q35.1 solute carrier family 34 (sodium phosphate), member 1 LOC345456 5q35.3 similar to profilin 3 F12 5q35.1 coagulation factor XII (Hageman factor) GPRK6 5q35 G protein-coupled receptor kinase 6 MGC10772 5q35.3 hypothetical protein MGC10772 DBN1 5q35.3 drebrin 1 FLJ22570 5q35.3 Dok-like protein DDX41 5q35.3 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 HSGP25L2G 5q35.3 gp25L2 protein LOC391854 5 similar to Beta-1,4-galactosyltransferase 7 (Beta-1,4-GalTase 7) (Beta4Gal-T7) (b4Gal-T7) (UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 7) (UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 7) ENIGMA 5q34-q35 similar to Beta-1,4-galactosyltransferase 7 (Beta-1,4-GalTase 7) (Beta4Gal-T7) (b4Gal-T7) (UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 7) (UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 7) FLJ10404 5q35.3 hypothetical protein FLJ10404 B4GALT7 5q35.2-q35.3 xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7 (galactosyltransferase I) LOC202181 5q35.3 hypothetical protein LOC202181 NY-REN-7 5q35.3 NY-REN-7 antigen LOC391855 5 similar to olfactory receptor MOR126-1 LOC389349 5 hypothetical gene supported by NM_032361
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 2662 - 193 - Yun (2007)
    6 - 1483 - 206 - Yun (2007)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Respiratorylung    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    cell cycle     cell cycle, S
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one helix-loop-helix domain
  • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies ortholog to murine Mxd3 (85 pc)
    Homologene
    FAMILY
  • bHLH family of transcription factor
  • MAD family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    text expressed specifically during the S-phase of the cell cycle in both proliferating and differentiating cells (Fox 2003)
    basic FUNCTION
  • represses transcription, when bound to MAX protein
  • necessary role for SHH-dependent granule neuron precursors proliferation (Yun 2007)
  • should antagonize MYCN by competition for direct DNA binding via Max dimerization (Yun 2007)
  • may be having a role in cellular proliferation and tumorigenesis (Barisone 2008)
  • promotes the segregation of nonexchange chromosomes that are not tethered by SLC39A1 at their centromeresb (Newnhan 2010)
  • negatively regulates B cell differentiation in the spleen by inducing ID2 expression
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • interacting with MAX
  • interacts with other DNA binding proteins to repress transcription (Yun 2007)
  • transcriptional target of E2F1 (Fox 2003)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS