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FLASH GENE
Symbol MXD1 contributors: mct/npt/pgu - updated : 09-09-2009
HGNC name MAX dimerization protein 1
HGNC id 6761
Location 2p14      Physical location : 70.142.202 - 70.170.074
Synonym name
  • MAD protein (MAX-binding protein)
  • MAX dimerizer
  • Synonym symbol(s) MAD, MAD1, MGC104659
    DNA
    TYPE functioning gene
    STRUCTURE 27.87 kb     6 Exon(s)
    regulatory sequence Promoter (CAAT box)
    text structure two CCAAT-boxes occupied by C/EBPalpha and beta in the homology region that mediate responsiveness to G-CSF receptor signaling
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 5587 25 221 - 1994 7829091
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
     intestine   highly
     mouthtongue  highly
     pharynx   highly
    Endocrineparathyroid   highly
    Lymphoid/Immunethymus   predominantly
    Reproductivemale systemprostate   
    Respiratorylung   moderately
     respiratory tractlarynx   
     respiratory tracttrachea  moderately
    Visualeye   moderately
    cell lineage
    cell lines
    fluid/secretion highly in blood
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a basic helix-loop-helix (bHLH) motif
  • a nuclear localization signal
  • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to rattus Mxd1 (89.6 pc)
    homolog to murine Mxd1 (89 pc)
    Homologene
    FAMILY
  • subfamily of MAX-interacting proteins
  • CATEGORY transcription factor , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • acting as a transcriptional repressor
  • antagonizing MYC transcriptional activity through interaction with the N-COR/SIN3/HDAC corepressor complex (by the recruitment of opposing chromatin remodeling activities compared to Myc)
  • inhibiting apoptosis via downregulation of PTEN expression
  • interacts with NEK2 at the kinetochore and possibly functions as a novel integrator of spindle checkpoint signaling
  • key role for the MYC-MAX-MXD1 network in the development and progression of neural crest tumors
  • CELLULAR PROCESS cell life, proliferation/growth
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    text multicellular organismal development
    PATHWAY
    metabolism
    signaling
    a component
  • forming a sequence-specific DNA-binding complex with MAX
  • part of the MYC-MAX-MXD1 network
  • INTERACTION
    DNA binding the enhancer box (E box) hexanucleotide (5-prime-CACGTG-3-prime) when heterodimerized with MAX
    RNA
    small molecule
    protein
  • Max heterodimeric partner
  • TERT telomerase reverse transcriptase
  • cell & other
    REGULATION
    induced by CSF3
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS