Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol MVD contributors: npt/ - updated : 08-01-2007
HGNC name mevalonate (diphospho) decarboxylase
HGNC id 7529
Location 16q24.3      Physical location : 88.718.347 - 88.729.495
Synonym name
  • mevalonate pyrophosphate decarboxylase
  • diphosphomevalonate decarboxylase
    • Synonym symbol(s) MPD, ER19, FP17780
    EC.number 4.1.1.33
    DNA
    TYPE functioning gene
    STRUCTURE 11.15 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 1812 43.3 400 - Toth (1996)
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveliver    
    Lymphoid/Immunespleen    
     thymus    
    Nervousbrain    
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Lymphoid    
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies ortholog to murine Mvd
    homolog to Drosophila CG8239
    homolog to C.elegans Y48B6A.13b
    Homologene
    FAMILY
  • diphosphomevalonate decarboxylase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • performing the first committed step in the biosynthesis of isoprenoids
  • catalysing conversion of mevalonate pyrophosphate into isopentenyl pyrophosphate by decarboxylation and dehydratation and ATP hydrolysis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    cholesterol and isoprenoids biosynthesis
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS