SUBCELLULAR LOCALIZATION
| intracellular
|
| intracellular,cytoplasm,organelle,Golgi
|
| intracellular,cytoplasm,organelle,endosome
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| intracellular,cytoplasm,cytosolic,vesicle
|
| intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
|
| intracellular,nucleus,nucleoplasm
|
text
| co-localized at the centrosome |
basic FUNCTION
| may be playing a key role in the ligand-mediated internalization and down-regulation of the EGF receptor |
|
with FAM125B, play a unique role in regulating ESCRT-mediated virus budding |
|
tyrosine-phosphorylated protein involved in the aggregation-prone proteins of FAM125B |
|
with FAM125B, have various biological roles within ESCRT-I, including their relationships to processes as endocytosis, virus budding, and cellular cytokinesis |
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its function is to promote the downregulation of EGF receptors that are recognized as a cargo protein |
|
selective association between MVB12A, MVB12B and VPS37 subunit family members generates distinct ESCRT-I complexes that correlate with different biological activities |