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FLASH GENE
Symbol MUC4 contributors: np/mct - updated : 11-03-2011
HGNC name mucin 4, cell surface associated
HGNC id 7514
Location 3q29      Physical location : 195.473.639 - 195.539.148
Synonym name
  • mucin 4, tracheobronchial
  • ascites sialoglycoprotein
  • testis mucin
  • pancreatic adenocarcinoma mucin
  • Synonym symbol(s) HSA276359, ASGP
    DNA
    TYPE functioning gene
    STRUCTURE 65.51 kb     25 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    motif repetitive sequence   other
    text structure VNTR
    MAPPING cloned Y linked   status provisional
    Physical map
    GP5 3q29 glycoprotein V (platelet) AFURS1 3q29 ATPase family homolog up-regulated in senescence cells LOC391605 3 similar to 60S ribosomal protein L23a LOC93109 3q29 hypothetical protein BC007772 FLJ11301 3q29 hypothetical protein FLJ11301 FLJ90022 3q29 hypothetical protein FLJ90022 LOC285303 3q29 similar to MGC27169 protein FLJ35155 3q29 hypothetical protein FLJ35155 CENTB2 3q29 centaurin, beta 2 PPP1R2 3q29 protein phosphatase 1, regulatory (inhibitor) subunit 2 LOC391606 3 similar to ribosomal protein L24 LOC255812 3q29 hypothetical protein LOC255812 LOC389187 3 LOC389187 MUC20 3q29 mucin 20 MUC4 3q29 mucin 4, tracheobronchial LOC285253 3q29 similar to SPBPJ4664.02 ACK1 3q29 activated Cdc42-associated kinase 1 LOC391607 3 hypothetical gene supported by AJ271448; NM_174907 LOC375386 3q29 similar to Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial precursor (Fp) (Flavoprotein subunit of complex II) LOC391608 3 hypothetical gene supported by AJ271448; NM_174907 TFRC 3q29 transferrin receptor (p90, CD71) ZDHHC19 3q29 zinc finger, DHHC domain containing 19 OSTalpha 3q29 organic solute transporter alpha PCYT1A 3q21-q28 phosphate cytidylyltransferase 1, choline, alpha isoform MGC33212 3q29 hypothetical protein MGC33212 LOC116211 3q29 hypothetical protein BC013113 KIAA0794 3q29 hypothetical protein BC013113 LOC389188 3 LOC389188 FLJ35794 3q29 hypothetical protein FLJ35794 LOC255798 3q29 hypothetical protein LOC255798 MGC64882 3q29 hypothetical protein MGC64882 LOC200933 3q29 hypothetical protein LOC200933 LOC389189 3 LOC389189 UNQ3030 3q29 ELLP3030 MGC14126 3q29 hypothetical protein MGC14126 FLJ20522 3q29 hypothetical protein FLJ20522 PAK2 3q29 p21 (CDKN1A)-activated kinase 2 MGC27076 3q29 hypothetical protein MGC27076 NCBP2 3q29 nuclear cap binding protein subunit 2, 20kDa LOC152217 3q29 hypothetical protein BC007882 SMP3 3q29 SMP3 mannosyltransferase LOC389190 3 similar to 40S ribosomal protein SA (P40) (34/67 kDa laminin receptor) (Colon carcinoma laminin-binding protein) (NEM/1CHD4) (Multidrug resistance-associated protein MGr1-Ag) MFI2 3q28-q29 antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5 LOC391609 3 similar to immediate early protein homolog DLG1 3q29 discs, large (Drosophila) homolog 1
    RNA
    TRANSCRIPTS type messenger
    text
  • five secreted and two membrane associated
  • alternative use of cassette exons, exon skipping or use of cryptic splice donor/acceptor sites
  • identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    25 - 17123 - 5412 - 1995 8654841
    also called variant 1/isoform a or sv0
    24 - 4415 4.51 1176 - 1995 8654841
    also called variant 4/isoform d or MUC4/Y
    23 - 4262 - 1125 - 1995 8654841
    also called variant 5/isoform e or MUC4/X
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon highly
     mouth   highly
     pharynx   highly
     stomach   highly
    Respiratoryrespiratory tracttrachea   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialabsorptive excretorydigestive epithelium  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Digestivegoblet
    Respiratorygoblet cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • variable tandem repeat (48bp) domain
  • one cysteine residue (VNTR) in the N terminal region,giving after cleavage the two subunits MUC4A, MUC4B, MUC4- beta possessing two EGF-like domains
  • a transmembrane sequence (1TM)
  • a potential phosphorylation site
  • conjugated GlycoP
    mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to rattus sialomucin
    Homologene
    FAMILY
    CATEGORY secretory
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • involved in intestinal epithelial cell differentiation
  • implicated in the integrity of the renewal of the epithelium
  • potentiates neuregulin signaling by increasing the cell-surface populations of ERBB2 and ERBB3
  • function as a modulator of cell signaling and provide mechanistic evidence for its role in pancreatic cancer progression
  • plays a role in ovarian cancer cell motility, in part, by altering actin arrangement and potentiating ERRB2 downstream signalling in these cells (
  • can act as a ligand/modulator for ERBB2, affecting its localization in polarized epithelial cells and its phosphorylation
  • heterodimeric membrane mucin implicated in epithelial differentiation and tumor progression
  • undergoes proteosomal degradation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ligand for Erb2 in cell signaling
  • target gene of ETV4 in pancreatic cancer cells (a transactivator of the MUC4 promoter through the -216 and -2368 ETV4 binding sites of the MUC4 promoter)
  • cell & other
    REGULATION
    Other regulated by TGFbeta, which represses the precursor cleavage
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in pancreatic carcinoma
    tumoral     --low  
    in ovarian epithelial cancer with increased cancer stage
    tumoral     --other  
    aberrantly expressed in 75p100 of pancreatic ductal adenocarcinomas
    tumoral     --over  
    in ovarian tumors and has a role in the invasiveness of OC cells
    tumoral     --over  
    in squamous cervical dysplasia and carcinomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • useful biological marker for the diagnosis of ductal adenocarcinomas
  • lineage marker in benign cervical tissue
  • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestiveoesophagus
    MUC1 and MUC4 may be attractive targets for the selection of treatment methods in oral squamous cell carcinoma (OSCC)
    ANIMAL & CELL MODELS