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FLASH GENE
Symbol MUC20 contributors: - updated : 24-02-2006
HGNC name mucin 20
HGNC id 23282
Location 3q29      Physical location : 195.447.752 - 195.464.539
Synonym symbol(s) FLJ14408, KIAA1359
DNA
TYPE functioning gene
STRUCTURE 12.00 kb     5 Exon(s)
MAPPING cloned Y linked N status provisional
Physical map
LOC254808 3q29 hypothetical protein LOC254808 LOC285280 3q29 similar to Carboxypeptidase N 83 kDa chain (Carboxypeptidase N regulatory subunit) LRRC15 3q29 leucine rich repeat containing 15 GP5 3q29 glycoprotein V (platelet) AFURS1 3q29 ATPase family homolog up-regulated in senescence cells LOC391605 3 similar to 60S ribosomal protein L23a LOC93109 3q29 hypothetical protein BC007772 FLJ11301 3q29 hypothetical protein FLJ11301 FLJ90022 3q29 hypothetical protein FLJ90022 LOC285303 3q29 similar to MGC27169 protein FLJ35155 3q29 hypothetical protein FLJ35155 CENTB2 3q29 centaurin, beta 2 PPP1R2 3q29 protein phosphatase 1, regulatory (inhibitor) subunit 2 LOC391606 3 similar to ribosomal protein L24 LOC255812 3q29 hypothetical protein LOC255812 LOC389187 3 LOC389187 MUC20 3q29 mucin 20 MUC4 3q29 mucin 4, tracheobronchial LOC285253 3q29 similar to SPBPJ4664.02 ACK1 3q29 activated Cdc42-associated kinase 1 LOC391607 3 hypothetical gene supported by AJ271448; NM_174907 LOC375386 3q29 similar to Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial precursor (Fp) (Flavoprotein subunit of complex II) LOC391608 3 hypothetical gene supported by AJ271448; NM_174907 TFRC 3q29 transferrin receptor (p90, CD71) ZDHHC19 3q29 zinc finger, DHHC domain containing 19 OSTalpha 3q29 organic solute transporter alpha PCYT1A 3q21-q28 phosphate cytidylyltransferase 1, choline, alpha isoform MGC33212 3q29 hypothetical protein MGC33212 LOC116211 3q29 hypothetical protein BC013113 KIAA0794 3q29 hypothetical protein BC013113 LOC389188 3 LOC389188 FLJ35794 3q29 hypothetical protein FLJ35794 LOC255798 3q29 hypothetical protein LOC255798 MGC64882 3q29 hypothetical protein MGC64882 LOC200933 3q29 hypothetical protein LOC200933 LOC389189 3 LOC389189 UNQ3030 3q29 ELLP3030 MGC14126 3q29 hypothetical protein MGC14126 FLJ20522 3q29 hypothetical protein FLJ20522 PAK2 3q29 p21 (CDKN1A)-activated kinase 2 MGC27076 3q29 hypothetical protein MGC27076 NCBP2 3q29 nuclear cap binding protein subunit 2, 20kDa LOC152217 3q29 hypothetical protein BC007882 SMP3 3q29 SMP3 mannosyltransferase LOC389190 3 similar to 40S ribosomal protein SA (P40) (34/67 kDa laminin receptor) (Colon carcinoma laminin-binding protein) (NEM/1CHD4) (Multidrug resistance-associated protein MGr1-Ag) MFI2 3q28-q29 antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5 LOC391609 3 similar to immediate early protein homolog DLG1 3q29 discs, large (Drosophila) homolog 1
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   moderately
Endocrineplacenta   moderately
Reproductivemale systemprostate  moderately
Respiratorylung   moderately
Urinarykidneytubuleconvoluted tubuleproximal tubulehighly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a mucin tandem repeat of 19 amino acids consisting of many threonine, serine, and proline residues and likely to be extensively O-glycosylated
  • HOMOLOGY
    interspecies ortholog to murine Muc20
    Homologene
    FAMILY mucin family
    CATEGORY regulatory , secretory
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • acting as a novel regulator of the Met signaling cascade which has a role in suppression of the Grb2-Ras pathway
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    immunoglobin A nephropathy
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS