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FLASH GENE
Symbol MUC20 contributors: - updated : 24-02-2006
HGNC name mucin 20
HGNC id 23282
Location 3q29      Physical location : 195.447.752 - 195.464.539
Synonym symbol(s) FLJ14408, KIAA1359
DNA
TYPE functioning gene
STRUCTURE 12.00 kb     5 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   moderately
Endocrineplacenta   moderately
Reproductivemale systemprostate  moderately
Respiratorylung   moderately
Urinarykidneytubuleconvoluted tubuleproximal tubulehighly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a mucin tandem repeat of 19 amino acids consisting of many threonine, serine, and proline residues and likely to be extensively O-glycosylated
  • HOMOLOGY
    interspecies ortholog to murine Muc20
    Homologene
    FAMILY mucin family
    CATEGORY regulatory , secretory
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • acting as a novel regulator of the Met signaling cascade which has a role in suppression of the Grb2-Ras pathway
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    immunoglobin A nephropathy
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS