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FLASH GENE
Symbol MUC17 contributors: mct - updated : 20-08-2010
HGNC name mucin 17, cell surface associated
HGNC id 16800
Location 7q22.1      Physical location : 100.663.363 - 100.702.140
Synonym name
  • intestinal membrane mucin MUC17
  • mucin 17
  • small intestinal mucin-3
  • secreted mucin MUC17
  • Synonym symbol(s) MUC3, MUC-17
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text clustered with MUC3B, MUC12, MUC3A
    STRUCTURE 38.78 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC392081 7 similar to insulin receptor substrate like protein LRRN4 7q22 leucine rich repeat neuronal 4 FBXO24 7q22 F-box only protein 24 PCOLCE 7q22 procollagen C-endopeptidase enhancer AF053356_CDS3 7q22 hypothetical protein AF053356_CDS3 TFR2 7q22 transferrin receptor 2 ACTL6 7q22 actin-like 6 GNB2 7q21.1-q22.2 guanine nucleotide binding protein (G protein), beta polypeptide 2 PERQ1 7q22 PERQ amino acid rich, with GYF domain 1 RPP20 7q22 POP7 (processing of precursor, S. cerevisiae) homolog EPO 7q21.3-q22.1 erythropoietin ZAN 7q22 zonadhesin EPHB4 7q32-q36 EphB4 LOC285995 7q22.1 hypothetical LOC285995 SLC12A9 7q22 solute carrier family 12 (potassium/chloride transporters), member 9 TRIP6 7q22 thyroid hormone receptor interactor 6 ARS2 7q21 arsenate resistance protein ARS2 ACHE 7q22.1 acetylcholinesterase (YT blood group) MUC3B 7q22 mucin 3B LOC219612 7q22.1 hypothetical gene supported by AK025404 MUC17 7q22 mucin 17 TRIM56 7q11.2 tripartite motif-containing 56 SERPINE1 7q21.3-q22.1 serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 AP1S1 7q11.22 adaptor-related protein complex 1, sigma 1 subunit VGF 7q22 VGF nerve growth factor inducible FLJ39237 7q22.1 FLJ39237 protein MGAT3 22q13.1 mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase PLOD3 7q36 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 ZNHIT1 7q22.1 zinc finger, HIT domain containing 1 CLDN15 7q22 claudin 15 TTC11 7q22.1 tetratricopeptide repeat domain 11 LOC392082 7 similar to Zn-alpha-2-glycoprotein precursor FLJ14117 COL26A1 7q22.1 collagen, type XXVI, alpha 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 14360 451.7 4493 - 2008 17990980
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon highly
     stomach   predominantly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialabsorptive excretorydigestive epithelium (mucosa) highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Digestiveenterocyte
    cell lineage
    cell lines colon and pancreatic cancer
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • extended, repetitive extracellular glycosylation domain,
  • extracellular regions with two EGF-like Cys-rich domains (CRD1 and CRD2) connected by an intervening linker segment with SEA module (L), that may function to stimulate intestinal cell restitution
  • a SEA module domain
  • a transmembrane domain
  • a cytoplasmic domain with potential serine and tyrosine phosphorylation sites
  • conjugated GlycoP , PhosphoP
    HOMOLOGY
    interspecies homolog to murine Muc3
    Homologene
    FAMILY
    CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • extracellular matrix constituent, lubricant activity
  • both native MUC17 and the exogenous recombinant cysteine-rich domain of MUC17 play a role in diverse cellular mechanisms related to cell restitution
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • exhibited a strong binding to PDZK1 (PDZK1 plays a specific role in stabilizing MUC17 in the apical membrane of small intestinal enterocytes)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in colonic mucosa of chronic ulcerative colitis and ischaemic colitis
    tumoral     --low  
    decreased in hyperplastic polyps, tubular and tubulovillous adenomas and colon cancers
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    immunologyautoimmunedigestive
    potential role for MUC17-CRD1-L-CRD2 recombinant protein in the treatment of mucosal inflammatory diseases
    ANIMAL & CELL MODELS