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FLASH GENE
Symbol MUC16 contributors: mct - updated : 19-01-2013
HGNC name mucin 16, cell surface associated
HGNC id 15582
Location 19p13.2      Physical location : 8.959.520 - 9.092.018
Synonym name
  • mucin 16
  • ovarian cancer antigen 125
  • ovarian cancer-related tumor marker CA125
    • Synonym symbol(s) CA125, FLJ14303, MUC-16
    DNA
    TYPE functioning gene
    STRUCTURE 132.50 kb     84 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    regionally located pter - D19S884 - D19S865 - MUC16 - D19S916 - D19S865 - cen
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    84 - 43 816 2500 14507 highly expressed in ovarian carcinomas 2002 12047385
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node    
    Respiratorylung    
    cell lineage
    cell lines SK-OV-8 and OVCAR-3 cells (ovarian cancer)
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a high serine threonine and proline content in an N-terminal region of 9 partially conserved tandem repeats
  • a SEA domain proposed to regulate carbohydrate side chain
  • a C terminal region non-tandem repeat sequence containing a possible transmembrane segment
  • a potential phosphorylation site
    • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to MUC16, Pan troglodutes
    ortholog to Muc16, Rattus norvegicus
    ortholog to Muc16, Mus musculus
    Homologene
    FAMILY
  • Mucins family
    • CATEGORY secretory
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • playing a role in ovarian cancer
  • immune protection provided by MUC16 may lead to selective survival of ovarian cancer cells that are more efficient in metastasizing within the peritoneal cavity and also at overcoming anti-tumor innate immune responses
  • cell surface mucin expressed at high levels by epithelial ovarian tumors
  • critical role of MUC16 in tumor cell growth, tumorigenesis and metastases
  • has a dual role in breast cancer cell proliferation by interacting with JAK2 and by inhibiting the apoptotic process through downregulation of TNFSF10
  • central role of MUC16 in cancer cell survival pathways, and might also be involved in adhesion, migration and invasion depending on the type of cancer cell
  • MUC16 and mesothelin (MSLN), are associated with the invasion process in patients with pancreatic ductal adenocarcinoma
  • released from ovarian tumors, and binding to NK cells and monocytes via the inhibitory receptor SIGLEC9
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction between mesothelin (MSLN) and MUC16 may facilitate the implantation and peritoneal spread of tumors by cell adhesion
  • MUC16-SIGLEC9 binding likely mediates inhibition of anti-tumor immune responses
  • selectin ligand expressed by metastatic pancreatic cancer cell
    • cell & other
  • MUC16 binding to NK cells and monocytes likely contributes to tolerance of the fetal allograft from maternal responses
    • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral        
    SELE and SELL ligand expressed by metastatic pancreatic cancer cells
    tumoral     --over  
    enhanced metastatic potential associated with MUC16 overexpression implicating a role of selectins in metastasis
    tumoral     --over  
    in breast cancer tissues whereas not expressed in non-neoplastic ducts
    constitutional     --over  
    increased in patients with acute coronary syndrome and systolic dysfunction or acute heart failure
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • CRP and MUC16 are elevating markers in preeclampsia
  • binding to NK cells and monocytes likely contributes to tolerance of the fetal allograft from maternal responses and may also serve as a novel biomarker for preeclampsia
    • Therapy target
    ANIMAL & CELL MODELS