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FLASH GENE
Symbol MTX2 contributors: mlc - updated : 26-10-2007
HGNC name metaxin 2
HGNC id 7506
Location 2q31.1      Physical location : 177.134.122 - 177.202.751
Synonym symbol(s) MGC111067
DNA
TYPE functioning gene
STRUCTURE 68.00 kb     10 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Map cen - D2S335 - TTN - MTX2 - D2S2257 - qter
Authors Gene Map (98)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 1385 - 263 - Xie (2007)
- - 1589 - 253 - Xie (2007)
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Hearing/Equilibriumear   highly
Reproductivemale systemtestis  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a glutathione S-transferase consensus sequence
  • lacking the C terminal outer membrane signal-anchor domain present in MTX1
    • HOMOLOGY
    interspecies homolog to C.elegans Cel ZC97.1
    Homologene
    FAMILY
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,outer
    basic FUNCTION putatively involved in protein import into mitochondria
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • metaxin binding
  • association with six other proteins, metaxins 1, CHCHD3, CHCHD6 and DNAJC11, SAMM50, IMMT (putative role in protein import related to maintenance of mitochondrial structure)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS