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FLASH GENE
Symbol MTX2 contributors: mlc - updated : 26-10-2007
HGNC name metaxin 2
HGNC id 7506
Location 2q31.1      Physical location : 177.134.122 - 177.202.751
Synonym symbol(s) MGC111067
DNA
TYPE functioning gene
STRUCTURE 68.00 kb     10 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Map cen - D2S335 - TTN - MTX2 - D2S2257 - qter
Authors Gene Map (98)
Physical map
KIAA1715 2q31 KIAA1715 LOC344191 2q31.2 similar to Homeobox even-skipped homolog protein 2 (EVX-2) HOXD13 2q31 homeo box D13 HOXD12 2q31 homeo box D12 HOXD11 2q31.1 homeo box D11 HOXD10 2q31 homeo box D10 HOXD9 2q31 homeo box D9 HOXD8 2q31 homeo box D8 HOXD4 2q31 homeo box D4 HOXD3 2q31 homeo box D3 HOXD1 2q31-q37 homeo box D1 LOC150978 2q31.2 similar to 60S acidic ribosomal protein P1 LOC129841 2q31.2 similar to 40S ribosomal protein SA (P40) (34/67 kDa laminin receptor) (Colon carcinoma laminin-binding protein) (NEM/1CHD4) (Multidrug resistance-associated protein MGr1-Ag) MTX2 2q24.3-q31 metaxin 2 LOC375295 2q31.2 hypothetical gene supported by BC013438
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 1385 - 263 - Xie (2007)
- - 1589 - 253 - Xie (2007)
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Hearing/Equilibriumear   highly
Reproductivemale systemtestis  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a glutathione S-transferase consensus sequence
  • lacking the C terminal outer membrane signal-anchor domain present in MTX1
  • HOMOLOGY
    interspecies homolog to C.elegans Cel ZC97.1
    Homologene
    FAMILY
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,outer
    basic FUNCTION putatively involved in protein import into mitochondria
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • metaxin binding
  • association with six other proteins, metaxins 1, CHCHD3, CHCHD6 and DNAJC11, SAMM50, IMMT (putative role in protein import related to maintenance of mitochondrial structure)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS