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FLASH GENE
Symbol MTX1 contributors: - updated : 19-05-2006
HGNC name metaxin 1
HGNC id 7504
Location 1q21      Physical location : 155.178.489 - 155.183.622
Synonym symbol(s) MTX, MTXN
DNA
TYPE functioning gene
SPECIAL FEATURE opposite orientation
text MTX1 and MTX1P in opposite orientation
STRUCTURE 4.00 kb     8 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Map cen - CLK2 - SCAMP3 - C1orf2 - GBA - MTX1P - GBAP - MTX1 - THBS3 - MUC1 - qter
Authors Long (96), Winfield (97)
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis  highly
Respiratorylung   highly
Skin/Tegumentskin   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a C terminal mitochondrial outer membrane signal-anchor domain
  • HOMOLOGY
    interspecies homolog to murine metaxin
    homolog to C.elegans CelF39B2.1
    Homologene
    FAMILY
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,outer
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION involved in postimplantation embryo survival
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
  • constituent of the protein translocation apparatus of the outer mitochondrial membrane proteins into mitochondria
  • INTERACTION
    DNA
    RNA
    small molecule
    protein association with six other proteins, metaxins 2, CHCHD3, CHCHD6 and DNAJC11, SAMM50, IMMT (putative role in protein import related to maintenance of mitochondrial
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS