protein
| NVL is a remodeling factor for the MTREX-exosome complex during the maturation of pre-ribosomal particles |
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WDR74 is a novel regulatory protein of the MTREX-exsosome complex whose interaction is regulated by NVL and is involved in ribosome biogenesis |
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competition between MTREX and ALYREF determines exosome recruitment and functions in creating balanced nuclear RNA pools for degradation and export |
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WDR74 associates with MTREX, the nuclear exosome-assisting RNA helicase, whose dissociation is prohibited by an ATPase-deficient mutant of the AAA-type chaperone NVL |
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dissociation of WDR74 from MTREX in a late stage of rRNA synthesis is thought to be required for appropriate maturation of the pre-60S particles |
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MTREX association with NRDE2, defines a novel function for MTREX in the DNA damage response pathway |
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NRDE2 inhibits MTREX recruitment and RNA degradation, and thereby ensures efficient mRNA nuclear export |
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WDR74 is a MTREX-interacting partner, whose dissociation is stimulated by the ATP hydrolysis of NVL |