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FLASH GENE
Symbol MTPN contributors: - updated : 23-03-2007
HGNC name myotrophin
HGNC id 15667
Location 7q33      Physical location : 135.611.504 - 135.662.204
Synonym name granule cell differentiation protein
Synonym symbol(s) FLJ31098, GCDP, V-1
DNA
TYPE functioning gene
STRUCTURE 50.00 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
FLJ32786 7q33 hypothetical protein FLJ32786 SLC35B4 7q33 solute carrier family 35, member B4 AKR1B1 7q25 aldo-keto reductase family 1, member B1 (aldose reductase) AKR1B10 7q33 aldo-keto reductase family 1, member B10 (aldose reductase) LOC392097 7 similar to aldo-keto reductase family 1, member B10; aldose reductase-like 1; aldo-keto reductase family 1, member B11 (aldose reductase-like); aldose reductase-like peptide; aldose reductase-related protein; small intestine reducta BPGM 7q32 2,3-bisphosphoglycerate mutase LOC392098 7 similar to beta-tubulin CALD1 7q33-q34 caldesmon 1 LOC340351 7q33 hypothetical protein LOC340351 LOC346671 7q33 pseudogene of RING finger protein 14 FLJ11000 7q33 hypothetical protein FLJ11000 MGC5242 7q33 hypothetical protein MGC5242 KIAA1466 7q33 KIAA1466 protein HSPC049 7q33 HSPC049 protein LOC346673 7q33 STRA8 LOC346674 7q33 similar to Na+/L-ascorbic acid transporter 1; SVCT1 CNOT4 7q33 CCR4-NOT transcription complex, subunit 4 LOC392099 7 hypothetical gene supported by AK075360; NM_003002 NUP205 7q33 nucleoporin 205kDa LOC136321 7q33 similar to 60S ribosomal protein L15 SLC13A4 7q33 solute carrier family 13 (sodium/sulfate symporters), member 4 LOC389558 7 similar to HWKM1940 MTPN 7q33-q35 myotrophin LOC392100 7 similar to protease (prosome, macropain) 26S subunit, ATPase 1 LOC389559 7 LOC389559 CHRM2 7q31-q35 cholinergic receptor, muscarinic 2 LOC389560 7 LOC389560 PTN 7q33-q34 pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1) DGKI 7q32.3-q33 diacylglycerol kinase, iota CREB3L2 7q33-q34 cAMP responsive element binding protein 3-like 2
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineparathyroid   highly
Reproductivefemale systembreastmammary gland highly
Skin/Tegumentskin   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three ANK repeats
  • putative phosphorylation sites for protein kinase C and caseine kinase 2
  • conjugated Other
    mono polymer monomer
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • playing a potential role in cerebellar morphogenesis
  • playing a potential role in differentiation of cerebellar neurons, particulary of granule cells
  • increasing the transcript levels of protooncogenes,beta-myosin heavy chain,ANF and markers of cardiac hypertrophy
  • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RELA (initiating cardiac hypertrophy )
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • candidate gene for cardiac hypertrophy and heart failure
  • Marker
    Therapy target
    ANIMAL & CELL MODELS