| protein
| FKBP12-rapamycin complex ( |
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gephyrin, GPHN |
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activates and posphorylates STAT3 |
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14-3-3tau |
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protein kinase cdelta, PKCdelta ( |
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c-Abl |
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a direct target of the PI3K-AKT signaling pathway in mitogen-stimulated cells |
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ubiquilin 1, UBQLN1 |
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regulatory associated protein of MTOR, complex 1, RPTOR |
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CLIP-170 |
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GbetaL |
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RPTOR independent companion of MTOR, complex 2, RICTOR |
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Ras homolog enriched in brain, RHEB ( |
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Rheb like-1 protein, RhebL1 |
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eukaryotic translation initiation factor 3, EIF3 |
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eukaryotic translation initiation factor 4E binding protein 1, 4EBP1 |
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phospholipase D2, PLD2 |
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proline-rich Akt/PKB substrate 40 kDa, PRAS40 ( |
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F-box and WD repeat domain containing 7, FBXW7 ( |
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PRR5L binds MTOR via Raptor, and is an MTOR phosphorylation substrate |
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folliculin, FLCN |
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specific interaction between MTOR and RPS6K2 with HNRNPF is implicated in the regulation of cell proliferation |
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AKT1S1 is a MTOR binding protein that has complex effects on cell metabolism |
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MAF1 homolog (S. cerevisiae), MAF1 and general transcription factor IIIC, polypeptide 1, alpha 220kDa, GTF3C1 in nuclei |
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IQ motif containing GTPase activating protein 1, IQGAP1 and AKT |
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an intact CRTC2 is required for efficient binding of MTOR, and rictor to translating ribosomes |
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RHEB is required for MTOR and myelination in postnatal brain development |
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influences cellular growth by phosphorylating RPS6KA1, a serine/threonine kinase that regulates S6 ribosomal protein and other members of the translational machinery |
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interacting with DGKZ (DGKZ and TCR engagement activate signaling in both MTOR complexes 1 and 2 through the activation of the Ras-Mek1/2-Erk1/2-AP-1 pathway |
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RAC1 is a critical regulator of both MTOR and CRTC2 in response to growth-factor stimulation (binding of RAC1 to MTOR does not depend on the GTP-bound state of RAC1, but on the integrity of its C-terminal domain) |
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interaction with PPP1R15A (PPP1R15A induced by starvation serves to suppress the MTOR pathway) |
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activation of MTOR is regulated by a small G-protein, RHEB |
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regulates SREBF by controlling the nuclear entry of LPIN1, a phosphatidic acid phosphatase |
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interacting with LPIN1 (constitutively dephosphorylated, nuclear form of LPIN1 is both necessary and sufficient for mediating the effects of MTOR inhibition on the expression of nuclear SREBF proteins) |
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MTOR is linked to a critical component of the late endosome/lysosome, ATP6V1H |
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AKT1 induces senescence in cells via MTOR and TP53 in the absence of DNA damage |
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SQSTM1 interacts in an amino acid-dependent manner with MTOR and RAPTOR |
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MTOR signaling is important to regulate the expression, activity and secretion of matrix metalloproteinases MMP9 |
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DEPTOR is an inhibitor of the MTOR kinase that is highly regulated at the posttranslational level |
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ATP6V0D2 is required for amino acid signaling to MTOR and functions between amino acids and the nucleotide loading of the Rag GTPases |
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phospholipase D, a PI(3)P effector, has been proposed to be a positive regulator of MTOR signaling and localization |
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influences the expression of PPARGC1A and therefore mitochondrial biogenesis through formation of a complex with PPARGC1A and the transcription factor YY1 |
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KHDRBS1 regulates MTOR alternative splicing during adipogenesis |
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LARS is a key mediator for amino acid signaling to MTOR |
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RAB5A is implicated in the activation of MTOR by insulin and nutrients |
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Wortmannin inhibits MTOR activity, independent of AKT1 |
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DDIT4 is a negative regulator of MTOR and its overexpression delays the onset of replicative senescence |
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CCL5 simultaneously activates AMPK and MTOR signaling cascades to regulate glucose uptake and chemotaxis in activated T cells |
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MARK4 is an AMP-activated kinase-related kinase, and a negative regulator of MTOR |
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RRAGA have a critical role in nutrient sensing by MTOR and in neonatal survival during fasting |
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UCHL1 is a key regulator of the dichotomy between MTOR and CRTC2 signaling |
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WDFY1 and LAMP2 can likely influence MTOR activity and regulate autophagy |
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RAB12 promotes constitutive degradation of SLC36A4, whose accumulation in RAB12-knockdown cells modulates MTOR activity and autophagy |
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during cellular stress the dual specificity kinase DYRK3 regulates the stability of P-granule-like structures and MTOR signaling |
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when DYRK3 is active, it allows stress granule dissolution, releasing MTOR for signaling and promoting its activity by directly phosphorylating the MTOR inhibitor AKT1S1 |
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specific domains of MTOR, RICTOR, or MAPKAP1 interacted with the internal domain (AA. 221-402) of NBN |
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BRSK2 is a unique pancreas-specific effector protein of MTOR signaling |
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link between HAP1 and TSC1 that regulates neuronal MTOR signaling and neuronal morphogenesis |
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controls mitochondrial activity and biogenesis by selectively promoting translation of nucleus-encoded mitochondria-related mRNAs via inhibition of the eukaryotic translation initiation factor EIF4EBP1, EIF4EBP2 |
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RPTOR in MTOR complex 1 is believed to recruit EIF4EBP1, facilitating phosphorylation of EIF4EBP1 by the kinase MTOR |
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liver MTOR controls IGF1 bioavailability by regulation of protein kinase CSNK2A1 and IGFBP1 phosphorylation in fetal growth restriction |
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GNGT1, GNG2, GNB1, GNB2, GNB3, interacts with MTOR and promotes its activation |
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CIP2A is a key modulator of MTOR and autophagy |
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TSC1, TSC2, negatively regulates the mammalian target of rapamycin complex 1 (MTOR) a master regulator of protein synthesis, cell growth and autophagy |
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AKT1S1 appears to reduce brain injury by converting cell signaling from AKT1 to MTOR |
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RAB12 regulates MTOR activity and autophagy through controlling SLC36A4 trafficking from recycling endosomes to lysosomes, where SLC36A4 is degraded |
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STX12 translation is regulated by MTOR in injured neurons to promote axon regeneration |
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nutrient-sensing MTOR kinase pathway controls the nucleolar targeting of SENP3 by regulating its interaction with NPM1 |
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MTOR activation inhibits eukaryotic translation initiation factor 4E-binding protein (EIF4EBP1) and activates ribosomal protein S6 kinase 1 (RPS6KB1), both of which stimulate translation |
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neuron-specific ARHGEF9 interacts with EIF3A, and its binding partner GPHN associates with MTOR |
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MTOR signaling inhibition ameliorates vascular calcification via Klotho upregulation |
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regulation of EIF4EBP1 in skeletal muscle may serve as an important conduit through which MTOR controls metabolism |
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BORCS6 is a LAMTOR1-interacting protein that regulates MTOR activity through its interaction with LAMTOR1 at the lysosome |
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interacts with both MTOR and its regulator RAB1A on the Golgi |
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MTOR is a functionally relevant target of FBXW7 in oligodendrocytes |
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sustained activation of MTOR signaling in skeletal muscle regulated whole-body metabolism through the induction of FGF21, which, over the long term, caused severe lipodystrophy |
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NPRL2 interacts with RPTOR in amino acid sufficiency to activate MTOR |
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CUL1 promoted MTOR activity and cap-dependent translation by enhancing the ubiquitination and degradation of DEPTOR |
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WAC is a regulator of energy-mediated MTOR activity |
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PKM activates MTOR signaling through phosphorylating MTOR inhibitor AKT1 substrate 1 (AKT1S1) |
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ZNRF2 appeared to augment MTOR and its downstream targets CCND1 and CDK in non-small cell lung cancer cells |
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phosphorylation of S348/S409 in LARP6 by MTOR stimulates the interaction of LARP6 and STRAP to coordinate translation of collagen mRNAs and to release LARP6 from the ER for new round of translation |
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MDM4 is a nutrient-sensor able to inhibit MTOR and highlight its metabolism-related tumor-suppressing function |
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MTOR regulates M6PR transport and T-cell vulnerability to regulatory T cells controlling kinesin KIF13A |
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function of RHEB to activate MTOR signaling |
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distinct roles of RHEB and RPTOR in activating MTOR for the self-renewal of hematopoietic stem cells |
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MTOR activation by RHEB and inhibition by AKT1S1 |
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TFEB-mediated endocytosis is a critical process leading to activation of MTOR and autophagic function, thus identifying the importance of the dynamic endolysosomal system in cellular clearance |
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TFEB nucleo-cytoplasmic shuttling suggest an unpredicted role of MTOR in nuclear export |
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biphasic roles of MTOR in osteoclastogenesis, dosage-dependent effects of rapamycin on bone, and a calcineurin-MTOR-NFATC1 phosphorylation-regulatory signaling cascade |
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SLC36A1 can likely negatively regulate MTOR by controlling the cellular nutrient signal level |
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WDR35 is associated with RRAGA, RRAGB, RRAGC and might negatively influence MTOR activity |
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SLC1A5 is critical for activation of MTOR activity by amino acids, and is a transcriptional target of MYC |
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PKD1 is required to couple mechanical deflection of cilia to MTOR in tubular cells |
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FNIP1 modulates autophagy and energy response pathways in part through the regulation of AMPK, MTOR, and TFE3 in B cell progenitors |
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TFE3 transcriptional activity |
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OTUD5 is a novel positive regulator of the MTOR and CRTC2 signaling pathways (PMISD: 33110214) |
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MTOR directly phosphorylated OTUD5 and activated its DUB activity |
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the amino acid-mediated activation of MTOR is regulated by the N-terminal domain of SLC38A9 |
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MTOR specifically controls TFEB and TFE3 cytosolic retention, whereas AMPK is essential for TFEB |
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UNK, a key regulator of cellular morphogenesis, is a novel substrate of MTOR |
