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FLASH GENE

Symbol

MTMR8

contributors: mct - updated : 01-06-2017

HGNC name	myotubularin related protein 8
HGNC id	16825

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	Xq11.2      Physical location : 63.487.961 - 63.615.333
Synonym symbol(s)	FLJ20126
EC.number	3.1.3.-

DNA

TYPE	functioning gene
STRUCTURE	127.37 kb     14 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_017677 14 - 2675 NP_060147 78.8 704 - 2015 26143924

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive female system ovary         male system prostate

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a phosphatase domain with a catalytic activity inhibited by oxidation and reversibly reactivated by reduction, suggesting the presence of an oxidation-protective intermediate other than a disulfide bond owing to the absence of a cysteine within a disulfide-bond distance from Cys338

HOMOLOGY

Homologene

FAMILY	protein-tyrosine phosphatase family
	non-receptor class myotubularin subfamily

CATEGORY

receptor membrane tyrosine phosphatase

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,nuclear envelope

basic FUNCTION	may be involved in the regulation of phosphatidylinositol 3-kinase (PI 3-kinase) pathway and membrane trafficking
	should potentially represent a novel element of the Hedgehog/PI3K/VEGF signaling cascade that controls arterial specification

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

MTMR6/MTMR9 complex serves to inhibit stress-induced apoptosis and the MTMR8/MTMR9 complex inhibits autophagy

INTERACTION

DNA

RNA

small molecule

protein

interaction of MTMR8 with MTMR9

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS