Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol MTMR4 contributors: mct - updated : 21-08-2014
HGNC name myotubularin related protein 4
HGNC id 7452
Location 17q22      Physical location : 56.566.892 - 56.595.251
Synonym name
  • FYVE domain-containing dual specificity protein phosphatase 2
  • zinc finger, FYVE domain containing 11
  • Synonym symbol(s) KIAA0647, FYVE-DSP2, ZFYVE11
    EC.number 3.1.3.48
    DNA
    TYPE functioning gene
    STRUCTURE 28.58 kb     19 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map cen - D17S791 - MYL4 - ITGB3 - HOXB5 - D17S806 - HOXB1 - HOXB2 - NGFR - D17S797 - D17S1795 - D17S809 - D17S941 - D17S788 - D17S787 - MTMR4 - MPO - D17S792 - D17S794 - qter
    Authors GeneMap (98)
    Physical map
    MRPS23 17q22-q23 mitochondrial ribosomal protein S23 C14orf34 14q23.2 chromosome 14 open reading frame 34 ZNF161 17q23.3 zinc finger protein 161 SFRS1 17q21.3-q22 splicing factor, arginine/serine-rich 1 (splicing factor 2, alternate splicing factor) Dlc2 17q23.2 dynein light chain 2 OR4D1 17q24.2 olfactory receptor, family 4, subfamily D, member 1 HSHPX5 17q23.2 HPX-5 LOC124538 17q23.2 similar to Olfactory receptor 4D2 EPX 17q24-q25 eosinophil peroxidase FLJ20345 17q23.2 hypothetical protein FLJ20345 LPO 17q23.1 lactoperoxidase MPO 17q22-q23.1 myeloperoxidase BZRAP1 17q22-q23 benzodiazapine receptor (peripheral) associated protein 1 SUPT4H1 17q21-q23 suppressor of Ty 4 homolog 1 (S. cerevisiae) FLJ20315 17q23.2 hypothetical protein FLJ20315 FLJ40311 17q23.2 hypothetical protein FLJ40311 MTMR4 1721.1-q23 myotubularin related protein 4 PNUTL2 17q22-q23 peanut-like 2 (Drosophila) FLJ40121 17q23.2 hypothetical protein FLJ40121 TEX14 17q22-q23 testis expressed sequence 14 RAD51C 17q22-q23 RAD51 homolog C (S. cerevisiae) PPM1E 17q23.2 protein phosphatase 1E (PP2C domain containing) TRIM37 17q22-q23 tripartite motif-containing 37 LOC348235 17q23.2 hypothetical protein LOC348235 FLJ11029 17q23.2 hypothetical protein FLJ11029 FLJ10587 17q23.2 hypothetical protein FLJ10587 FLJ37451 17q23.2 hypothetical protein FLJ37451
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    19 - 5847 133.3 1195 - 1998 9736772
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a double-helical motif similar to the SET interaction domain
  • FYVE-type zinc finger
  • conjugated ubiquitinated
    HOMOLOGY
    intraspecies homolog to myotubularin protein 4
    Homologene
    FAMILY
  • protein-tyrosine phosphatase family
  • non-receptor class myotubularin subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic
    text
  • localizes at the interface of early and recycling endosomes to regulate trafficking through this pathway
  • basic FUNCTION
  • protein/tyrosine/phosphatase activity
  • plays potentially an important role in preventing the overactivation of TGFbeta signaling by dephosphorylating activated R-Smads that have been trafficked to early endosomes
  • is also an essential negative regulator of BMP signaling pathway
  • CELLULAR PROCESS protein, post translation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • inositol phosphatase, MTMR4 (myotubularin-related protein 4), identified as a novel interactor of the ubiquitin ligase NEDD4
  • attenuates TGFbeta signaling by reducing the phosphorylation level of R-Smads in early endosomes
  • directly bound to and dephosphorylated the activated SMAD1 via the DUSP enzymatic domain, and SMAD1 dephosphorylation would require an endosome-localized phosphatase activity of MTMR4
  • interacted with SMAD1 and SMAD5
  • cell & other
    REGULATION
    Other ubiquitinated by NEDD4, suggesting that this novel interaction may underlie the biological process of muscle breakdown
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS