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FLASH GENE

Symbol

MTL5

contributors: npt/ - updated : 07-07-2008

HGNC name	metallothionein-like 5, testis-specific (tesmin)
HGNC id	7446

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	11q13.2      Physical location : 68.474.909 - 68.518.988
Synonym name	CXC domain containing 2
	testis-specific metallothionein-like protein
Synonym symbol(s)	TSML, MTLT, TESMIN, CXCDC2

DNA

TYPE	functioning gene
STRUCTURE	44.08 kb     10 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 10 - 2535 isoform a 55 508 - - variant 2 - - 3625 isoform b 32.2 306 - -

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive male system testis     specific

cell lineage	spermatocytes, early marker of male germ cell differentiation
cell lines
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

cysteine rich with two metallothionein-like motifs

conjugated

PhosphoP , MetalloP

HOMOLOGY

interspecies

homolog to murine Mtl5

Homologene

FAMILY

metallothionein family of heavy-metal binding proteins

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION

basic FUNCTION	playing a role in the regulation of cell growth and differentiation
	protecting against heavy-metal toxicity

CELLULAR PROCESS	cell life, differentiation
	cell life, proliferation/growth
	cell life, antiapoptosis

PHYSIOLOGICAL PROCESS

reproduction/sex

text	spermatogenesis

PATHWAY

metabolism

metal

signaling

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	heavy metal ions

protein

cell & other

REGULATION

induced by

heavy metal ions

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS