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FLASH GENE
Symbol MTF2 contributors: mct - updated : 18-08-2011
HGNC name metal response element binding transcription factor 2
HGNC id 29535
Location 1p22.1      Physical location : 93.544.791 - 93.604.636
Synonym name
  • likely ortholog of mouse metal response element binding transcription factor 2
  • Polycomb-like 2
  • Synonym symbol(s) M96 , PCL2, RP5-976O13.1, dJ976O13.2
    DNA
    TYPE functioning gene
    STRUCTURE 59.85 kb     15 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 - 4144 - 593 - 2004 15563832
    14 - 3973 - 536 - 2004 15563832
    16 - 4064 - 491 - 2004 15563832
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinethyroid   highly
    Lymphoid/Immunelymph node   highly
     tonsils   highly
    Nervousbrain    
    Reproductivefemale systemuteruscervix highly
    Respiratorylung    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text highly in embryonic stem cells
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a Tudor domains that selectively bind to histone H3K36me3
  • two PHD-type zinc fingers
  • FYVE domains
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory , DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • binding to the metal-regulating-element (MRE) of metallothionein 1A gene promoter
  • may be involved in regulation of transcription, DNA-dependent
  • functions in collaboration with both PRC2 and PRC1 to repress Hox gene expression during axial development
  • important in cell fate decisions and may play a role in recruitment of PRC2 to target genes and histone methylation
  • with JARID2, are important regulatory subunits of PRC2 in embryonic stem (ES) cell
  • common function of PHF1, MTF2 and PHF19 is recruitment of the PRC2 complex to its target genes for histone methylation, Hox gene silencing and ESC (Extra Sex Combs) self-renewal
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • forms a complex with PRC2 and binds to Hox genes in a PRC2-dependent manner
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • differentially regulates Polycomb-mediated repression of Hox and CDKN2A genes
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS