Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol MTF1 contributors: SGE/npt - updated : 26-09-2015
HGNC name metal-regulatory transcription factor 1
HGNC id 7428
Location 1p34.3      Physical location : 38.275.238 - 38.325.292
Synonym name
  • MRE-binding transcription factor-1
  • zinc regulatory factor
  • metal-responsive transcription factor 1
  • Synonym symbol(s) MGC23036, MTF-1, ZRF
    DNA
    TYPE functioning gene
    STRUCTURE 50.05 kb     11 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 7986 - 753 - 2004 1522626
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepancreas   highly
     thyroid   highly
    Reproductivefemale systembreastmammary gland highly
    Visualeye   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • six C2H2-type zinc fingers
  • a SUMO-interacting motif (SIM)
  • conserved C-terminus of the cysteine-rich domain provides cadmium specificity
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    text localizes to both the cytoplasm and the nucleus but quantitatively accumulates in the nucleus upon metal load and under other stress conditions (Lindert 2009)
    basic FUNCTION
  • activating the metallothionein 1 promoter
  • having a critical role in embryonic liver formation, heavy metal toxicity, and hematopoiesis (Wang 2004)
  • plays a central role in hypoxic cells by contributing to HIF-1 activity (Murphy 2005)
  • required for copper-mediated regulation of the PRNP gene (Bellingham 2009)
  • direct role of MTF1 in promoter-specific binding and initiation
  • essential mammalian protein for embryonic development and modulates the expression of genes involving in zinc homoeostasis and responding to oxidative stress
  • recognizes a specific DNA sequence motif termed the metal response element (MRE), located in the promoter/enhancer region of its target genes
  • is essential for the induction of genes encoding metallothionein by metals and hypoxia
  • is a sequence-specific DNA binding protein that activates the transcription of metal responsive genes
  • MTF1 chooses different DNA binding sites depending on the specific nature of the metal insult
  • zinc-SLC39A8-MTF1 axis is an essential catabolic regulator of osteoarthritis pathogenesis
  • Metallothionein (MT) and MTF1 are important regulatory proteins involved in the mediation of intracellular metal ion balance (pMID: 25405524)
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • cysteine cluster mediates homodimerization of MTF1, and dimer formation is important for basal and especially metal-induced transcriptional activity
  • forms complexes with cellular factors through SIM and SUMO moiety in the cytoplasm
  • INTERACTION
    DNA binds to metal responsive element
    RNA
    small molecule
    protein
  • SLC30A2 participates in zinc transport into pancreatic zymogen granules through a glucocorticoid pathway requiring glucocorticoid receptor and STAT5, and zinc-regulated signaling pathways requiring MTF1
  • associates with MTF1 in the cells, and protein but not lipid phosphatase activity of PTEN was involved in the regulation of MTF1 activity
  • cell & other
    REGULATION
    activated by prolyl-hydroxylase inhibitors that can activate MTF1, but this activation requires the presence of HIF1A
    Other MTF1 DNA-binding activity was strongly enhanced in the presence of zinc but not by hypoxia
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS