Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
Symbol MTF1 contributors: SGE/npt - updated : 26-09-2015
HGNC name metal-regulatory transcription factor 1
HGNC id 7428
Location 1p34.3      Physical location : 38.275.238 - 38.325.292
Synonym name
  • MRE-binding transcription factor-1
  • zinc regulatory factor
  • metal-responsive transcription factor 1
  • Synonym symbol(s) MGC23036, MTF-1, ZRF
    TYPE functioning gene
    STRUCTURE 50.05 kb     11 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    PDE4DIP 1q12 phosphodiesterase 4D interacting protein (myomegalin) LOC388776 1 similar to AG02 LOC391202 1 similar to Tissue alpha-L-fucosidase precursor (Alpha-L-fucosidase I) (Alpha-L-fucoside fucohydrolase) LOC388763 1 similar to Ankrd3-prov protein LOC391208 1 similar to mCAF1 protein LOC388764 1 similar to hypothetical protein MGC3047 MTF1 1p34-p32 metal-regulatory transcription factor 1 DKFZp434K1323 1p36.33 CXYorf1-related protein LOC388570 1 similar to hypothetical protein CNR2 1p36.11 cannabinoid receptor 2 (macrophage) LOC391210 1 similar to Olfactory receptor 2T3 FLJ23550 1q23.3 hypothetical protein FLJ23550 LOC391205 1 similar to RIKEN cDNA B230396O12 DKFZp434D177-likLOC391204 LOC391204 1 similar to plectin LOC391211 1 similar to Olfactory receptor 2G3 MGC10334 1p36.33 hypothetical protein MGC10334 LOC388777 1 similar to hypothetical protein DJ328E19.C1.1 SH120 1p36.13-q31.3 putative G-protein coupled receptor MMP23B 1p36.3 matrix metalloproteinase 23B CDC2L2 1p36.33 cell division cycle 2-like 2 CDC2L1 1p36.33 cell division cycle 2-like 1 (PITSLRE proteins) LOC391201 1 similar to hypothetical protein FLJ10709 LOC391212 1 similar to Olfactory receptor 2T5 S100A3 1q21 S100 calcium binding protein A3 LOC391203 1 similar to 14.5 kDa translational inhibitor protein (p14.5) (UK114 antigen homolog) LOC388765 1 hypothetical gene supported by BK000152 LOC391209 1 similar to ribosomal protein L36; 60S ribosomal protein L36 PNRC2 1p36.11 proline-rich nuclear receptor coactivator 2 LOC391213 1 similar to seven transmembrane helix receptor LOC388766 1 hypothetical gene supported by BC059409; NM_022834 LOC388770 1 similar to TBP-associated factor 1A isoform 1; SL1, 48kD subunit FUSIP1 1p36.11 FUS interacting protein (serine-arginine rich) 1
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 7986 - 753 - 2004 1522626
    Type widely
       expressed in (based on citations)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepancreas   highly
     thyroid   highly
    Reproductivefemale systembreastmammary gland highly
    Visualeye   highly
    cell lineage
    cell lines
    at STAGE
  • six C2H2-type zinc fingers
  • a SUMO-interacting motif (SIM)
  • conserved C-terminus of the cysteine-rich domain provides cadmium specificity
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    text localizes to both the cytoplasm and the nucleus but quantitatively accumulates in the nucleus upon metal load and under other stress conditions (Lindert 2009)
    basic FUNCTION
  • activating the metallothionein 1 promoter
  • having a critical role in embryonic liver formation, heavy metal toxicity, and hematopoiesis (Wang 2004)
  • plays a central role in hypoxic cells by contributing to HIF-1 activity (Murphy 2005)
  • required for copper-mediated regulation of the PRNP gene (Bellingham 2009)
  • direct role of MTF1 in promoter-specific binding and initiation
  • essential mammalian protein for embryonic development and modulates the expression of genes involving in zinc homoeostasis and responding to oxidative stress
  • recognizes a specific DNA sequence motif termed the metal response element (MRE), located in the promoter/enhancer region of its target genes
  • is essential for the induction of genes encoding metallothionein by metals and hypoxia
  • is a sequence-specific DNA binding protein that activates the transcription of metal responsive genes
  • MTF1 chooses different DNA binding sites depending on the specific nature of the metal insult
  • zinc-SLC39A8-MTF1 axis is an essential catabolic regulator of osteoarthritis pathogenesis
  • Metallothionein (MT) and MTF1 are important regulatory proteins involved in the mediation of intracellular metal ion balance (pMID: 25405524)
  • CELLULAR PROCESS nucleotide, transcription
    a component
  • cysteine cluster mediates homodimerization of MTF1, and dimer formation is important for basal and especially metal-induced transcriptional activity
  • forms complexes with cellular factors through SIM and SUMO moiety in the cytoplasm
    DNA binds to metal responsive element
    small molecule
  • SLC30A2 participates in zinc transport into pancreatic zymogen granules through a glucocorticoid pathway requiring glucocorticoid receptor and STAT5, and zinc-regulated signaling pathways requiring MTF1
  • associates with MTF1 in the cells, and protein but not lipid phosphatase activity of PTEN was involved in the regulation of MTF1 activity
  • cell & other
    activated by prolyl-hydroxylase inhibitors that can activate MTF1, but this activation requires the presence of HIF1A
    Other MTF1 DNA-binding activity was strongly enhanced in the presence of zinc but not by hypoxia
    corresponding disease(s)
    Variant & Polymorphism
    Candidate gene
    Therapy target