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Symbol MTERF4 contributors: mct - updated : 06-10-2014
HGNC name mitochondrial transcription termination factor 4
HGNC id 28785
Location 2q37.3      Physical location : -
Synonym name
  • mTERF domain-containing protein 2
  • mitochondrial termination factor 2
  • Synonym symbol(s) MGC61716, MTERFD2, FLJ16261, HSPC096,
    DNA
    TYPE virus associated
    STRUCTURE 27.65 kb     7 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 1657 44 381 - 2010 20430012
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Endocrineparathyroid    
    Lymphoid/Immunespleen    
     thymus    
    Reproductivefemale systemuterus   
    Respiratorylung    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a 270 AAs long MTERF-domain required for DNA binding and transcription regulation , MTERF-motifs that form a nucleic acid binding domain
  • repetitions of a 30 AA module, the mTERF motif, containing leucine zipper-like heptads b
  • secondary structure MTERF-motif containing three alpha-helices separated by loops
    mono polymer monomer
    isoforms Precursor at mature MTERF2 lacks a targeting peptide (AAs 1-35) present in the precursor form of the protein
    HOMOLOGY
    Homologene
    FAMILY
  • mTERF family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION
  • with MTERFD1, and MTERFD3 regulate transcription by acting in the same site in the mtDNA promoter region and thereby mediate fine-tuning of mitochondrial transcription and hence OXPHOS function
  • displays a non sequence-specific DNA-binding activity
  • implicated in modulating transcription, replication and protein synthesis
  • directly controls mitochondrial ribosomal biogenesis and translation
  • is an important regulator of translation in mammalian mitochondria
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • NSUN4/MTERF4 complex is required to assemble the small (SSU) and large subunit (LSU) of ribosome to form a monosome
  • INTERACTION
    DNA
    RNA bind RNA and plays an essential role as a regulator of ribosomal biogenesis in mammalian mitochondria
    small molecule
    protein
  • interacts with mtDNA and is a member of the nucleoid
  • binds to the mtDNA promoter region, suggesting that it affects transcription initiation
  • NSUN4 is thus a dual function protein, which on the one hand is needed for 12S rRNA methylation and, on the other hand interacts with MTERF4 to facilitate monosome assembly
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS