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FLASH GENE
Symbol MTDH contributors: mct/npt/pgu - updated : 11-06-2015
HGNC name metadherin
HGNC id 29608
Location 8q22.1      Physical location : 98.656.406 - 98.742.487
Synonym name
  • LYRIC/3D3
  • astrocyte elevated gene-1
  • metastasis adhesion protein
  • lyric protein
  • lysine-RIch CEACAM1 co-isolated protein
  • Synonym symbol(s) 3D3, AEG-1, AEG1, LYRIC
    DNA
    TYPE functioning gene
    STRUCTURE 85.96 kb     12 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 7667 63.8 582 - 2008 18440304
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineparathyroid   highly
    Hearing/Equilibriumear   highly
    Lymphoid/Immunelymph node   highly
    Respiratoryrespiratory tractlarynx  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,nucleus,nucleoplasm,nuclear bodies
    intracellular,nucleus,nucleolus
    intracellular,nuclear envelope
    text
  • type-1b membrane protein
  • with ZBTB16, colocalize to nuclear bodies containing histone deacetylases, which are known to promote ZBTB16-mediated repression
  • basic FUNCTION
  • HIV-1-inducible gene, recruited during the maturation of the tight junction complex (part of the tight junction complex)
  • promote tumor cell migration and invasion through activation of the transcription factor NFKB
  • may be involved in the connection between nuclear envelope and the endoplasmic reticulum
  • playing an important role in tumor development, progression and metastasis through activation of the NFKB pathway
  • plays a central role in Ha-ras-mediated oncogenesis through the phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway
  • may function as an oncogene
  • may affect tumor progression in multiple cell lineages by augmenting expression of the transformed phenotype and/or by inducing glutamate excitotoxicity in malignant glioma
  • important factor promoting progression or metastasis of a variety of tumors
  • may represent an essential gene regulating multiple signaling and biochemical pathways leading to cell transformation and tumor progression in diverse target cells
  • plays a crucial role in both oncogenic transformation and angiogenesis, which are essential components in tumor cell development, growth, and progression to metastasis
  • directly contributes to resistance to chemotherapeutic drugs, another important hallmark of aggressive cancers
  • potential regulator of protective autophagy, an important feature of MTDH that may contribute to its tumor-promoting properties
  • induces autophagy in a Beclin-1- and class III PI3 kinase-independent manner, and this effect is mediated through up-regulation of ATG5
  • promotes gliomagenesis, particularly in the context of tumor growth and invasion
  • contributes to glioma-induced neurodegeneration, a hallmark of this fatal tumor, through regulation of SLC1A2 expression
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component complexing with SND1 and dual role of the MTDH-SND1 complex in suppressing the apoptotic response and promoting breast cancer development
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • target gene of oncogenic HRAS requiring phosphatidylinositol 3-kinase and MYC
  • negative regulator of BCCIP, promoting proteasomal degradation either through direct interaction, or potentially through an indirect mechanism involving downstream effects of the NFKB signaling pathway
  • interacting with ZBTB16
  • SND1 is a novel MTDH-interacting protein and it is a functionally and clinically significant mediator of metastasis
  • AKR1C2 (positive factor) and NF1 (negative factor), are the MTDH downstream players in the process of metastasis in liver cancer
  • cell & other
    REGULATION
    activated by by LH in the primate corpus luteum
    induced by oncogenic HRAS (activates MTDH promoter by the PI3K pathway)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in metastatic breast cancer
    constitutional     --over  
    in astrocytes infected with HIV-1 or treated with GP120 or tumor necrosis factor (TNF)-alph
    tumoral     --over  
    in breast and prostate tumors, melanoma and glioblastoma
    tumoral     --other  
    aberrant expression plays a dominant positive role in regulating oncogenic transformation and angiogenesis
    tumoral     --over  
    in more than 90p100 of brain tumors
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    may provide a viable target for directly suppressing the cancer phenotype
    ANIMAL & CELL MODELS