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FLASH GENE
Symbol MTCH1 contributors: mct - updated : 27-11-2010
HGNC name mitochondrial carrier homolog 1 (C. elegans)
HGNC id 17586
Location 6p21.2      Physical location : 36.935.916 - 36.953.949
Synonym name
  • CGI-64 protein
  • presenilin-associated protein
  • cell proliferation-inducing protein 60
  • mitochondrial carrier homolog 1
  • Synonym symbol(s) CGI-64, PSAP, PIG60
    DNA
    TYPE functioning gene
    STRUCTURE 18.77 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    C6orf81 6p21.31 chromosome 6 open reading frame 81 LOC389383 6 similar to AAAL3045 LOC340204 6p21.31 similar to precursor peptide CLPS 6p22-p21.1 colipase, pancreatic MGC33835 6p21.31 hypothetical protein MGC33835 SRPK1 6p213-p21.2 SFRS protein kinase 1 SLC26A8 6p21 solute carrier family 26, member 8 MAPK14 6p21.2 mitogen-activated protein kinase 14 MAPK13 6p21.1 mitogen-activated protein kinase 13 BRPF3 6p21 bromodomain and PHD finger containing, 3 PNPLA1 6p21.31 patatin-like phospholipase domain containing 1 LOC389384 6 similar to RIKEN cDNA 4930539E08 ETV7 6p21 ets variant gene 7 (TEL2 oncogene ) STEPP 6p21.31 small testis-specific peroxisomal protein C6orf69 6p21.31 chromosome 6 open reading frame 69 STK38 6p21 serine/threonine kinase 38 SFRS3 11p15.1 splicing factor, arginine/serine-rich 3 LOC389385 6 similar to Cytosol aminopeptidase (Leucine aminopeptidase) (LAP) (Leucyl aminopeptidase) (Proline aminopeptidase) (Prolyl aminopeptidase) LOC389386 6 similar to Cytosol aminopeptidase (Leucine aminopeptidase) (LAP) (Leucyl aminopeptidase) (Proline aminopeptidase) (Prolyl aminopeptidase) CDKN1A 6p21.2 cyclin-dependent kinase inhibitor 1A (p21, Cip1) LOC346190 6p21.31 similar to hypothetical protein FLJ31614 LOC391917 6 similar to putative G-protein coupled receptor CPNE5 6p21.1 copine V PPIL1 6p21.1 peptidylprolyl isomerase (cyclophilin)-like 1 C6orf89 6p21.31 chromosome 6 open reading frame 89 PI16 6p21.31 protease inhibitor 16 MTCH1 6pter-p24.1 mitochondrial carrier homolog 1 (C. elegans) FGD2 6p21.2 FGD1 family, member 2 LOC285849 6p21.31 similar to cytochrome c oxidase subunit VIa polypeptide 1 precursor; cytochrome C oxidase subunit VIa homolog LOC389387 6 similar to 60S ribosomal protein L12 PIM1 6p21.2 pim-1 oncogene C6orf128 6p21.31-p21.2 chromosome 6 open reading frame 128 C6orf197 6p21.2 chromosome 6 open reading frame 197 RNF8 6p21.3 ring finger protein (C3HC4 type) 8 KIAA0082 6p21.2 ring finger protein (C3HC4 type) 8 C6orf129 6p21.2 chromosome 6 open reading frame 129 MDGA1 6p21 MAM domain containing glycosylphosphatidylinositol anchor 1 TEX27 6pter-p22.3 testis expressed sequence 27 BTBD9 6p21 BTB (POZ) domain containing 9
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 1890 39.9 372 - 2007 17670888
  • isoform 1
  • differ of isoform 2 in the length of a hydrophilic loop located between two predicted transmembrane domains
  • - splicing - - - - 2007 17670888
  • differ of isoform 1 in the length of a hydrophilic loop located between two predicted transmembrane domains
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   lowly
    Nervousbrain   predominantly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a PDZ-like domain and several protein kinase C and tyrosine phosphorylation sites, PDZ domain and N-terminal fragment are required for the pro-apoptotic activity
  • a mitochondrial carrier domain conserved in several inner membrane carriers, which partially overlaps one of the predicted transmembrane segments
  • multiple mitochondrial targeting motifs dispersed along the protein but that a transmembrane domain in the correct position and orientation is necessary for membrane insertion
  • HOMOLOGY
    interspecies homolog to murine Mtch1
    Homologene
    FAMILY
  • mitochondrial carrier family
  • CATEGORY regulatory , transport channel
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,outer
    intracellular,cytoplasm,organelle,membrane
    text integral mitochondrial outer membrane protein
    basic FUNCTION
  • positive regulator of apoptosis
  • induces cytochrome c release, independtly of caspase activation
  • mitochondrial apoptotic protein
  • apoptosis induced by MTCH1 likely involves the permeability transition pore
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • presenilin 1-associated protein, interacting with the C terminus of PSEN1
  • in addition to APAF1 or apoptosome formation, DIABLO is also essential for MTCH1-induced apoptosis
  • both the formation of cytochrome c-APAF1 apoptosome and the presence of DIABLO are absolutely required for MTCH1-induced apoptosis
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS