Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol MTA3 contributors: mct/npt - updated : 03/10/2008
HGNC name metastasis associated 1 family, member 3
HGNC id 23784
Location 2p21      Physical location : 42.795.670 - 42.936.352
Synonym name metastasis associated protein homolog
Synonym symbol(s) KIAA1266
DNA
TYPE functioning gene
STRUCTURE 140.68 kb     14 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
14 - 1872 - 515 - Zhang (2006)
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunethymus   highly
Nervousbrain   moderately
Reproductivefemale systemovary  moderately
Respiratoryrespiratory tractlarynx  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal highly
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/ImmuneB cell
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text brain moderately
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a BAH domain
  • a ELM2 domain
  • a GATA-type zinc finger
  • 1 MYB-like domain
  • HOMOLOGY
    interspecies ortholog to murine Mat3
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text cytoplasmic (short isoform) or nuclear (long isoform)
    basic FUNCTION
  • may be involved in the regulation of gene expression by covalent modification of histone proteins
  • playing a prominent role in B-cell fate determination
  • represses WNT4 transcription and WNT4 secretion, inhibiting WNT-target genes in mammary epithelial cells
  • upstream physiologic repressor of WNT4 in mammary epithelial cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • MTA3-NuRD (nucleosome remodeling and deacetylase) complex physically interacts with the WNT4 chromatin in an HDAC-dependent manner
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with BCL6
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS