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FLASH GENE
Symbol MTA2 contributors: mct - updated : 17-06-2014
HGNC name metastasis associated 1 family, member 2
HGNC id 7411
Location 11q12.3      Physical location : 62.360.674 - 62.369.303
Synonym name
  • metastasis-associated 1-like 1
  • MTA1-L1 protein
  • p53 target
  • protein in deacetylase complex
  • Synonym symbol(s) MAT2, PID, MTA1-L1, MTA1L1
    DNA
    TYPE functioning gene
    STRUCTURE 8.64 kb     18 Exon(s)
    regulatory sequence Promoter
    Binding site   transcription factor
    text structure
  • transcriptional activity of MTA2 promoter could be enhanced by Sp1 overexpression, and Sp1 regulates MTA2 expression at transcriptional level
  • MAPPING cloned Y linked N status provisional
    Physical map
    SCGB2A1 11q13 secretoglobin, family 2A, member 1 SCGB1D2 11q13 secretoglobin, family 1D, member 2 SCGB2A2 11q13 secretoglobin, family 2A, member 2 ASRGL1 11q12.3 asparaginase like 1 SCGB1A1 11q12.2-q13.1 secretoglobin, family 1A, member 1 (uteroglobin) MGC5395 11q12.2 hypothetical protein MGC5395 EEF1G 11q13.2 eukaryotic translation elongation factor 1 gamma FLJ22347 11q12.2 hypothetical protein FLJ22347 MTA2 11q12-q13.1 metastais-associated gene family, member 2 FLJ35827 11q12.3 hypothetical protein FLJ35827 ROM1 11q13.1 retinal outer segment membrane protein 1 B3GAT3 11q12.2 beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I) G2AN 11q12.3 alpha glucosidase II alpha subunit KIAA1698 11q12.3 KIAA1698 protein MGC2477 11q12.3 hypothetical protein MGC2477 LOC51035 11q12.3 ORF LOC221091 11q12.3 similar to hypothetical protein BSCL2 11q12.q13.5 Bernardinelli-Seip congenital lipodystrophy 2 (seipin) GNG3 11p11 guanine nucleotide binding protein (G protein), gamma 3 DKFZp762N1910 11q12.3 hypothetical protein DKFZp762N1910 MGC29649 11q12.3 hypothetical protein MGC29649 ZBTB3 11q12.3 zinc finger and BTB domain containing 3 POLR2G 11q13.1 polymerase (RNA) II (DNA directed) polypeptide G TAF6L 11q13.1 TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa LOC387617 11 hypothetical gene supported by NM_018336 LOC374395 11q12.3 similar to RIKEN cDNA 1810059G22 NXF1 11q12-q13 nuclear RNA export factor 1 STX5A 11cen-q12.1 syntaxin 5A FLJ10439 11q12.3 hypothetical protein FLJ10439 SLC3A2 11q12-q22 solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    18 - 3069 - 668 - 1999 9929979
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis    Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    ReproductiveSertoli cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a BAH domain
  • a ELM2 domain
  • a SANT domain similar to the DNA binding domain of myb-related proteins
  • a GATA-like zinc-finger domain
  • mono polymer complex
    HOMOLOGY
    interspecies ortholog to murine Mta2
    ortholog to rattus Mta2
    intraspecies paralog to MTA1
    Homologene
    FAMILY
  • NURD complex family (nucleosome remodeling deacetylase complex)
  • metastasis associated family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome,nucleosome
    basic FUNCTION
  • may be involved in the regulation of gene expression as repressor and activator
  • regulating histone deacetylase core complex enzymatic activity
  • modulating TP53-mediated cell growth arrest and apoptosis
  • participates in the down-regulation of FSHR transcription
  • required for TIPIN-dependent Polymerase alpha binding to replicating chromatin, and this function is essential to prevent the accumulation of reversed forks
  • CELLULAR PROCESS cell life, proliferation/growth
    cell life, cell death/apoptosis
    nucleotide, chromatin organization, remodeling
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component of the NuRD nucleosome remodeling deacetylase complex with HDAC1, HDAC2, histone binding proteins and MBD3
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • ion Zn2+
  • protein
  • interacting with HDAC7, TP53, MINT and MBD3
  • potent corepressor of FSHR transcription, because it can recruit histone deacetylase-1 onto the FSHR promoter and participates in the down-regulation of FSHR expression upon FSH treatment
  • SETD6 associated with HDAC1 and MTA2
  • is a novel TIPIN binding partner and mediator of its function
  • cell & other
    REGULATION
    induced by directly by testosterone or indirectly by FSH, and is exclusively expressed in Sertoli cells
    Other association of MTA1L1 with the core histone deacetylase complex mediated by MBD3
    post-translational regulation of MTA2 by the way of EP300-dependent acetylation, which is important for tumor cells growth and migration and provides a potential target for clinical cancer research
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral        
    increasing metastatic potential of certain carcinomas
    tumoral     --over  
    in several solid tumors and associated with tumor cells migration and invasion
    tumoral     --over  
    tight correlation between the MTA2 expression level and hepatocellular carcinoma size and differentiation
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • cytoplasmic CTNND1, cytoplasmic ZBTB33, and nuclear MTA2 expression correlated directly with histological type and Masaoka stage and may thus be used as potential biomarkers to predict biological behavior of thymoma
  • Therapy target
    ANIMAL & CELL MODELS