SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,cytosolic
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| intracellular,cytoplasm,cytoskeleton,microtubule
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| intracellular,nucleus,nucleoplasm
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| intracellular,nucleus,chromatin/chromosome,nucleosome
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| intracellular,nuclear envelope
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| basic FUNCTION
| nuclear regulatory factor, implicated in cellular transformation, in part through its ability to regulate the epithelial-to-mesenchymal transition and metastasis |
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corepressor of estrogen receptor alpha (ESR1), and transcriptional activator of Breast Cancer Amplified Sequence 3 (BCAS3) |
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playing a role as an upstream modifier of SIX3, a direct stimulator of rhodopsin expression, thus revealing a putative role for the MTA1/SIX3/rhodopsin pathway in vertebrate eye |
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involved in regulating transcription and this may be accomplished by chromatin remodeling |
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may operate as a negative modifier of apoptosis by interacting with TP53 during gametogenesis  |
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destabilizes RFWD2 by promoting its autoubiquitination, thus creating a tight feedback loop that regulates both MTA1 and RFWD2 protein stability |
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required for optimum DNA double-strand break repair after ionizing radiation |
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role in DNA double-strand break (DSB) repair, and having an integral role in the nucleosome remodeling and histone-deacetylase (NuRD) complexes |
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required for optimum DNA double-strand break repair after ionizing radiation |
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required for MYD88-dependent stimulation of NFKB signaling and expression of proinflammatory cytokines such as IL1B, MIP2, and TNF1 |
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involved in regulation of MYD88 which may constitute at least one of the mechanisms by which MTA1 stimulates LPS-induced NFkB signaling in stimulated macrophages |
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TP53-independent function in DNA damage response via modulation of the CDKN1A-proliferating cell nuclear antigen pathway |
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in addition to its role in the repair of double strand breaks caused by ionizing radiation, MTA1 also participates in the UV-induced ATR-mediated DNA damage checkpoint pathway |
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integral component of the nucleosome remodeling and deacetylase complex, implicated in the ionizing radiation-induced DNA damage response |
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first upstream modifier of GNAI2 gene expression and promotes Ras signalling |
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seems to be an important upstream modifier of GNAI2 expression and, consequently, could influence the activation of the Ras pathway, at least in part |
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master chromatin modifier, regulating the expression of HMMR and, consequently, its function in breast cancer cell motility and invasiveness |
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upstream coactivator of HMMR and is needed for its expression and resulting functions in invasion and migration |
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role for MTA1 in maintenance of circadian rhythmicity through acting on the positive limb of the clock machinery |
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participate in the DNA damage response beyond its well-established roles in gene transcription |
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MTA1 promotes the proliferation of epithelial ovarian cancer cells by enhancing DNA repair |
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MTA1 plays an important role in Epithelial-to-mesenchymal transition (EMT) to promote metastasis via suppressing CDH1 expression, resulting in a poor prognosis in malignant pleural mesothelioma (MPM) |
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critical homeostatic role of MTA1, both as a target and as a component of the neuronal oxidative stress, in the regulation of acute neuronal responses against brain I/R damage |
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cytoplasmic translocation of MTA1 coregulator promotes de-repression of SGK1 transcription in hypoxic cancer cells |
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MTA1 potentially promoted pancreatic cancer metastasis via HIF1A/VEGF pathway |
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MTA1-S100A4-MYH9 axis exists in endothelial cells as a novel pathway in promoting tumor vascular formation |
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is a chromatin modifier and its expression is significantly associated with prognosis of many cancers |
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MTA1 coregulator regulates LDHA expression and function in breast cancer |
