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FLASH GENE
Symbol MT1F contributors: mct - updated : 22-10-2015
HGNC name metallothionein 1F (functional)
HGNC id 7398
Location 16q13      Physical location : 56.691.854 - 56.693.214
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
STRUCTURE 1.36 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
Map see MT1@
Physical map
AMFR 16q21 autocrine motility factor receptor CPSF5 16q13 cleavage and polyadenylation specific factor 5, 25 kDa FLJ10826 16q13 hypothetical protein FLJ10826 BBS2 16q21 Bardet-Biedl syndrome 2 MT4 16q13 metallothionein IV MT3 16q13 metallothionein 3 (growth inhibitory factor (neurotrophic)) MT2A 16q13 metallothionein 2A MT1L 16q13 metallothionein 1L MT1E 16q13 metallothionein 1E (functional) MT1K 16q13 metallothionein 1K MT1J 16q13 metallothionein 1J MT1A 16q13 metallothionein 1A (functional) LOC390733 16 similar to MTM MT1B 16q13 metallothionein 1B (functional) MT1F 16q13 metallothionein 1F (functional) MT1G 16q13 metallothionein 1G MT1H 16q13 metallothionein 1H MT1X 16q13 metallothionein 1X KIAA0095 16q13 metallothionein 1X
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 498 - 44 - 2013 23064051
3 - 456 - 61 - 2013 23064051
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated MetalloP
HOMOLOGY
Homologene
FAMILY
CATEGORY regulatory , storage , tumor suppressor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
intracellular,nucleus
basic FUNCTION
  • inhibited function of MT1F in cancer growth
  • is a putative tumor suppressor gene in colon carcinogenesis that is downregulated mainly by LOH in colon cancer tissue
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    heavy metal ions
    protein
    cell & other
    REGULATION
    induced by heavy metal ions
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    downregulated in colon cancer tissue
    constitutional     --low  
    significantly down-regulated in proliferating keloid fibroblast (KF)
    tumoral     --low  
    in the liver cancer tissue
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • levels of MT1F and MT2A mRNA could be considered as new markers of poor prognosis of non-small cell lung cancer patients
  • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestiveliver
    may have an important role in gene therapy of hepatocellular carcinoma
    ANIMAL & CELL MODELS