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FLASH GENE
Symbol MT1B contributors: npt/ - updated : 24-09-2004
HGNC name metallothionein 1B (functional)
HGNC id 7394
Location 16q13      Physical location : 56.685.810 - 56.687.115
Synonym name metallothionein 1Q
Synonym symbol(s) MT1, MTP, MT1Q, MT-IB
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
STRUCTURE 1.31 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Map see MT1@
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 403 6 61 - West (1990)
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines hepatoma and renal carcinoma cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two metal-binding domains
    • conjugated MetalloP , Other
    mono polymer monomer
    HOMOLOGY
    Homologene
    FAMILY
  • metallothionein superfamily
  • type 1 family
    • CATEGORY regulatory , storage
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • acting in metal homeostasis
  • protecting against heavy-metal toxicity
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS detoxification
    text
  • metal homeostasis
  • against heavy-metal toxicity
    • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • heavy metal ions, Zn2+, Cu2+, cadmium Cd2+
    • protein
    cell & other
    REGULATION
    induced by heavy metal ions
    glucocorticoids
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS