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FLASH GENE
Symbol MT1B contributors: npt/ - updated : 24-09-2004
HGNC name metallothionein 1B (functional)
HGNC id 7394
Location 16q13      Physical location : 56.685.810 - 56.687.115
Synonym name metallothionein 1Q
Synonym symbol(s) MT1, MTP, MT1Q, MT-IB
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
STRUCTURE 1.31 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Map see MT1@
Physical map
AMFR 16q21 autocrine motility factor receptor CPSF5 16q13 cleavage and polyadenylation specific factor 5, 25 kDa FLJ10826 16q13 hypothetical protein FLJ10826 BBS2 16q21 Bardet-Biedl syndrome 2 MT4 16q13 metallothionein IV MT3 16q13 metallothionein 3 (growth inhibitory factor (neurotrophic)) MT2A 16q13 metallothionein 2A MT1L 16q13 metallothionein 1L MT1E 16q13 metallothionein 1E (functional) MT1K 16q13 metallothionein 1K MT1J 16q13 metallothionein 1J MT1A 16q13 metallothionein 1A (functional) LOC390733 16 similar to MTM MT1B 16q13 metallothionein 1B (functional) MT1F 16q13 metallothionein 1F (functional) MT1G 16q13 metallothionein 1G MT1H 16q13 metallothionein 1H MT1X 16q13 metallothionein 1X KIAA0095 16q13 metallothionein 1X
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 403 6 61 - West (1990)
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines hepatoma and renal carcinoma cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two metal-binding domains
  • conjugated MetalloP , Other
    mono polymer monomer
    HOMOLOGY
    Homologene
    FAMILY
  • metallothionein superfamily
  • type 1 family
  • CATEGORY regulatory , storage
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • acting in metal homeostasis
  • protecting against heavy-metal toxicity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS detoxification
    text
  • metal homeostasis
  • against heavy-metal toxicity
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • heavy metal ions, Zn2+, Cu2+, cadmium Cd2+
  • protein
    cell & other
    REGULATION
    induced by heavy metal ions
    glucocorticoids
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS