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FLASH GENE
Symbol MT-TL1 contributors: mct/npt - updated : 21-01-2025
HGNC name mitochondrially encoded tRNA leucine 1 (UUA/G)
HGNC id 7490
Corresponding disease
MELAS mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes syndrome
MERRF myoclonic epilepsy associated with ragged-red fibers
MTDM mitochondrial diabetes mellitus with deafness
Location mt      Physical location : -
Synonym name tRNA leucine 1 (UUA/G)
Synonym symbol(s) MTTL1, TRNL1
DNA
TYPE small rna
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type untranslated transfer
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
HOMOLOGY
Homologene
FAMILY
CATEGORY
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,mitochondria
basic FUNCTION
CELLULAR PROCESS
PHYSIOLOGICAL PROCESS
PATHWAY
metabolism
signaling
a component
INTERACTION
DNA
RNA
small molecule
protein
cell & other
REGULATION
ASSOCIATED DISORDERS
corresponding disease(s) MELAS , MERRF , MTDM
Susceptibility to maternal inherited diabetes with hearing loss
Variant & Polymorphism other mutation increasing the risk of maternal inherited diabetes with hearing loss
Candidate gene
Marker
  • methylations of MT-CO1, MT-CO3, and MT-TL1 may represent a novel intrinsic predictor of CVD risk in adults with overweight and obesity
    • Therapy target
    ANIMAL & CELL MODELS