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FLASH GENE
Symbol MT-ND4L contributors: np - updated : 13-03-2006
HGNC name mitochondrially encoded NADH dehydrogenase 4L
HGNC id 7460
Corresponding disease
LHON Leber hereditary optic neuropathy
Location mt      Physical location : -
Synonym name
  • NADH-ubiquinone oxidoreductase chain 4L
  • NADH dehydrogenase subunit 4L
  • Synonym symbol(s) ND4L, MTND4L, NAD4L, NADH4L
    EC.number 1.6.5.3
    DNA
    TYPE fragile site
    SPECIAL FEATURE overlapping, gene in gene
    STRUCTURE 0.00 kb     1 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 1668 10 98 - -
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES Hydrophobic
    STRUCTURE
    mono polymer heteromer , complex
    HOMOLOGY
    interspecies ortholog to murine Mt-Nd4l
    homolog to C.elegans Y58A7A.2
    Homologene
    FAMILY complex I subunit 4L family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    basic FUNCTION
  • catalysing reduction of ubiquinone on ubiquinol by NADH in the respiratory chain
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism energetic
    signaling
    a component
  • one of the forty one subunits of complex 1, probably located in the hydrophobic fragment
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) LHON
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral somatic mutation      
    in colorectal cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS